DORFIN Antibody

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Western Blot: DORFIN Antibody [NBP1-71860] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-Dorfin antibody used for IP at 6 mcg/mg lysate. Dorfin was also ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml
 

Independent Antibodies

       

Order Details

DORFIN Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 600 and 650 of human Double Ring-Finger Protein using the numbering given in entry NP_056250.3 (GeneID 25897).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RNF19A
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunoprecipitation 2-10 mcg/mg

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for DORFIN Antibody

  • DKFZp566B1346
  • dorfin
  • Double ring-finger protein
  • E3 ubiquitin-protein ligase RNF19A
  • EC 6.3.2
  • EC 6.3.2.-
  • p38
  • protein p38 interacting with transcription factor Sp1
  • RING finger protein 19 isoform
  • ring finger protein 19
  • ring finger protein 19Ap38 protein
  • ring-IBR-ring domain containing protein Dorfin
  • RNF19

Background

RNF19A contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB.The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol RNF19A
Uniprot