DORFIN Products

Antibodies
Lysates
DORFIN Overexpression Lysate
DORFIN Overexpression Lysate
NBL1-15441
Species: Hu
Applications: WB
DORFIN Overexpression Lysate
DORFIN Overexpression Lysate
NBP2-04770
Species: Hu
Applications: WB
Proteins
Recombinant Human DORFIN GST ...
Recombinant Human DORFIN GST (N-Te...
H00025897-Q01
Species: Hu
Applications: WB, ELISA, MA, AP
DORFIN Recombinant Protein An ...
DORFIN Recombinant Protein Antigen
NBP1-87989PEP
Species: Hu
Applications: AC

Description

Dorfin is an E3 ubiquitin ligase which mediates ubiquitination of cellular proteins. Dorfin contains two RING-finger motifs and an IBR (in between RING fingers) motif. Dorfin interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. Dorfin is of interest in Parkinson's Disease, as it binds and ubiquitylates synphilin 1 (SNCAIP - interacts with alpha synuclein) in neurons. Furthermore, Dorfin expression is increased in Lewy bodies, the characteristic neuronal inclusions in Parkinson's diseased brains. In normal subjects, Dorfin is widely expressed at low levels with higher levels found in the heart and is ubiquitously expressed in the central nervous system. Alternatively spliced transcript variants encoding the same protein have been reported.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Alternate Names
  • DKFZp566B1346
  • DORFIN
  • Dorfin
  • dorfin
  • Double ring-finger protein
  • E3 ubiquitin-protein ligase RNF19A
  • EC 6.3.2
  • EC 6.3.2.-
  • p38
  • protein p38 interacting with transcription factor Sp1
  • RING finger protein 19 isoform
  • ring finger protein 19
  • ring finger protein 19Ap38 protein
  • ring-IBR-ring domain containing protein Dorfin
  • RNF19

Research Areas for DORFIN

Find related products by research area and learn more about each of the different research areas below.

Zinc Finger