DORFIN Products

Antibodies
DORFIN Antibody
DORFIN Antibody
NBP1-87989
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
DORFIN Antibody
DORFIN Antibody
NB300-873
Species: Hu, Po, Bv, Ca
Applications: PEP-ELISA
Host: Goat Polyclonal
DORFIN Antibody
DORFIN Antibody
NBP1-71860
Species: Hu
Applications: WB, IP
Host: Rabbit Polyclonal
Lysates
DORFIN Overexpression Lysate ...
DORFIN Overexpression Lysate (Native)
NBL1-15441
Applications: WB
DORFIN Overexpression Lysate ...
DORFIN Overexpression Lysate (Native)
NBP2-04770
Applications: WB
Proteins
Recombinant Human DORFIN Prot ...
Recombinant Human DORFIN Protein
H00025897-Q01
Species: Hu
Applications: WB, ELISA, PA
DORFIN Recombinant Protein An ...
DORFIN Recombinant Protein Antigen
NBP1-87989PEP
Species: Hu
Applications: AC
RNAi
DORFIN RNAi
DORFIN RNAi
H00025897-R02
Species: Hu
Applications: RNAi, RNAi SP
DORFIN RNAi
DORFIN RNAi
H00025897-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Dorfin is an E3 ubiquitin ligase which mediates ubiquitination of cellular proteins. Dorfin contains two RING-finger motifs and an IBR (in between RING fingers) motif. Dorfin interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. Dorfin is of interest in Parkinson's Disease, as it binds and ubiquitylates synphilin 1 (SNCAIP - interacts with alpha synuclein) in neurons. Furthermore, Dorfin expression is increased in Lewy bodies, the characteristic neuronal inclusions in Parkinson's diseased brains. In normal subjects, Dorfin is widely expressed at low levels with higher levels found in the heart and is ubiquitously expressed in the central nervous system. Alternatively spliced transcript variants encoding the same protein have been reported.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 25897
Alternate Names
  • EC 6.3.2
  • E3 ubiquitin-protein ligase RNF19A
  • p38
  • DORFIN
  • EC 6.3.2.-
  • ring finger protein 19
  • Dorfin
  • dorfin
  • ring-IBR-ring domain containing protein Dorfin
  • RNF19
  • RING finger protein 19 isoform
  • Double ring-finger protein
  • protein p38 interacting with transcription factor Sp1
  • DKFZp566B1346
  • ring finger protein 19Ap38 protein

Pathways for DORFIN

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Transport
Cell Death
Glycosylation
Spermatid Development
Pathogenesis

Research Areas for DORFIN

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Zinc Finger

PTMs for DORFIN

Learn more about PTMs related to DORFIN.

Ubiquitination
Glycosylation

Bioinformatics Tool for DORFIN

Discover related pathways, diseases and genes to DORFIN. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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