Cytosolic Sulfotransferase 1E1/SULT1E1 Antibody [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 647

Cytosolic Sulfotransferase 1E1/SULT1E1 Antibody [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human Sulfotransferase 1E1/SULT1E1 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross‑reactivity with recombinant human (rh) Sulfotransferase 1A1 is observed and less than 2% cross‑reactivity with rhSulfotransferase 2A1 and rhSulfotransferase 4A1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cytosolic Sulfotransferase 1E1/SULT1E1 Antibody [Alexa Fluor™ Plus 647]

• Cytosolic Sulfotransferase 1E1
• EC 2.8.2
• EST-1
• ESTMGC34459
• estrone sulfotransferase
• ST1E1
• STE
• STEestrogen sulfotransferase
• Sulfotransferase 1E1
• sulfotransferase family 1E, estrogen-preferring, member 1
• Sulfotransferase, estrogen-preferringEC 2.8.2.4
• SULT1E1

Background

Cytosolic Sulfotransferases catalyze the sulfation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. They are distinct from Golgi resident sulfotransferases by the absence of transmembrane domains and are located in the cytoplasm. SULT1E1 is widely known as an estrogen sulfotransferase and may control estrogen levels by converting free estradiol to its inactive sulfate conjugate (1). Known substrates of this enzyme also include dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol, 4-nitrophenol, 1-napthol and resveratrol (2, 3). SULT1E1 activity is found in reproductive organs (4), intestine and liver (3, 5).

1. Gong, H. et al. (2008) Cancer Res. 68:7386.
2. Falany, C.N. et al. (1995) J. Steroid Biochem. Mol. Biol. 52:529.
3. Miksits, M. et al. 2005, Xenobiotica 35:1101.
4. Takase, Y. et al. (2007) The Prostate 67:405.
5. Schrag, M.L. et al. (2004) Drug Metabolism and Disposition 32:1299.
Robbins, P.W. (1962) Methods in Enzymology, Vol. V, Academic Press, Inc., New York, 964.
MacRae, I.J., I.H. Segel, and A.J. Fisher. (2000) Biochemistry. 39: 1613.
Wu, Z.L., et al. (2002) Faseb J. 16:539.

 

 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.