Cystatin B/Stefin B Antibody (227807) [Alexa Fluor® 532]

• Reactivity: Mu
• Applications: IHC
• Clone: 227807
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 532

Cystatin B/Stefin B Antibody (227807) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant mouse Cystatin B
  Met2-Phe98
  Accession # Q62426
• Specificity: Detects mouse Cystatin B in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant human (rh) Cystatin B is observed and no cross-reactivity with rhCystatin A, C, D, E/M, F, S, SA, rhFetuin A, rhFetuin&n
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cystatin B/Stefin B Antibody (227807) [Alexa Fluor® 532]

• CPI-B
• CST6cystatin B (liver thiol proteinase inhibitor)10STFBcystatin-B
• CSTB
• cystatin B (stefin B)
• Cystatin B
• EPM1
• Liver thiol proteinase inhibitor
• PME
• Stefin B
• stefin-B

Background

Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily (1). Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases of the papain family such as cathepsins B, H and L (2). Cystatin B-deficient mice have increased expression of proteolysis, apoptosis and glial activation genes, which is consistent with the pathology found in the mouse model of human progressive myoclonus epilepsy (EPM1) (3). The mouse Cystatin B consists of 98 amino acid residues (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.