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HAF019). A specific band was detected for Cystatin B at approximately 11 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank">
HAF017). A specific band was detected for Cystatin B at approximately 12 kDa (as indicated) in the parental HEK293T cell line, but is not detectable in knockout HEK293T cell line. GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
HAF018). A specific band was detected for Cystatin B at approximately 12 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
1408-PI) that has been preincubated with increasing concentrations of Human Cystatin B Monoclonal Antibody (Catalog # MAB1408). The ND50 is typically 5.4 µg/mL." class="big_lightbox" target="_blank">
HAF018). A specific band was detected for Cystatin B at approximately 12 kDa (as indicated) in the parental HEK293T cell line, but is not detectable in knockout HEK293T cell line. GAPDH (Catalog # MAB5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
![Western Blot Cystatin B/Stefin B Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_AF1408_Western_Blot_16738.jpg)
![Western Blot Cystatin B/Stefin B Antibody (225228) [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_MAB1408_Western_Blot_19584.jpg)
![Simple Western Cystatin B/Stefin B Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_AF1408_Simple_Western_18688.jpg)
![Knockout Validated Cystatin B/Stefin B Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_AF1408_Knockout_Validated_22991.jpg)
![Neutralization Cystatin B/Stefin B Antibody (225228) [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_MAB1408_Block_Neutralize_11272.jpg)
![Knockout Validated Cystatin B/Stefin B Antibody (225228) [Unconjugated]](http://images.novusbio.com/images/antibody/Cystatin_B_MAB1408_Knockout_Validated_22992.jpg)
