Cyclin D3 Antibody (DCS-22)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-Fr, IHC-P
Clone
DCS-22
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Cyclin D3 Antibody (DCS-22) Summary

Immunogen
Recombinant human cyclin D3
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
CCND3
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:20-1:40
Application Notes
This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. 0.01M Sodium citrate buffer pH6.0 is recommended for this purpose.
Publications
Read Publication using NBP1-51744.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
No buffer
Preservative
0.9% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for Cyclin D3 Antibody (DCS-22)

  • CCND3
  • Cyclin D3
  • D3-type cyclin
  • G1/S-specific cyclin D3
  • G1/S-specific cyclin-D3

Background

Cyclin D3 is a member of Cyclin D family which mediates cell cycle progression through the G1 phase. Cyclin D family binds and activates cyclin-dependent kinases 4 and 6 (CDK4, CDK6), which regulates the phosphorylation of retinoblastoma (Rb) protein, p107, and p130 (1). Cyclin D3, similar to cyclin D1 and D2, regulates the initial G1 to S transition by inhibiting Rb and activating E2F proteins (2). Cyclin D3 expression has been linked to inhibition of granulocyte differentiation and activation of various transcription factors, such as transcription factor 5 (3, 4). Overexpression of cyclin D3 is associated with poor clinical outcome in diffuse large B-cell lymphoma cases (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Cyclin D3 Antibody (NBP1-51744)(1)


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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol CCND3
Entrez
Uniprot