Cyclin D3 Antibody (588726) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 588726
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Cyclin D3 Antibody (588726) [Alexa Fluor® 405] Summary

• Immunogen: E.coli-derived recombinant human Cyclin D3
  Met1-Leu292
  Accession # P30281
• Specificity: Detects human Cyclin D3 in direct ELISAs. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) Cyclin B1 and D1 is observed. No cross-reactivity with rhCyclin A1, A2, B2, C, D2, E1, or E2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Cyclin D3 Antibody (588726) [Alexa Fluor® 405]

• CCND3
• Cyclin D3
• D3-type cyclin
• G1/S-specific cyclin D3
• G1/S-specific cyclin-D3

Background

Cyclin D3 is a 37 kDa cell cycle regulatory protein whose expression level and nuclear/cytoplasmic distribution are tightly regulated in synchrony with the cell cycle. Cyclin D3 complexes containing Cdk4 or Cdk6 induce phosphorylation of Rb, a requirement for progression through the G1/S cell cycle transition. Human Cyclin D3 shares 95% and 93% amino acid sequence identity with mouse and rat Cyclin D3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.