CUGBP1/CELF1 Antibody (850717) [Alexa Fluor® 700]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clone: 850717
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

CUGBP1/CELF1 Antibody (850717) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human CUGBP1/CELF1
  Met1-Gly60
  Accession # Q92879
• Specificity: Detects human CUGBP1/CELF1 in direct ELISAs and Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CUGBP1/CELF1 Antibody (850717) [Alexa Fluor® 700]

• BRUNOL2
• BRUNOL250 kDa nuclear polyadenylated RNA-binding protein
• bruno-like 2
• Bruno-like protein 2
• CELF1
• CUG RNA-binding protein
• CUG triplet repeat, RNA binding protein 1
• CUG triplet repeat, RNA-binding protein 1
• CUG-BP- and ETR-3-like factor 1
• CUGBP Elav-like family member 1
• CUG-BP
• CUGBP, Elav-like family member 1
• CUGBP1
• CUG-BP1
• CUGBP1CUG triplet repeat RNA-binding protein 1
• CUGBPCELF-1
• D2Wsu101e
• Deadenylation factor CUG-BP
• EDEN-BP homolog
• EDEN-BP
• embryo deadenylation element binding protein
• Embryo deadenylation element-binding protein homolog
• HNAB50
• NAB50
• NAB50CUG-BP1
• NAPOR
• nuclear polyadenylated RNA-binding protein, 50-kD
• RNA-binding protein BRUNOL-2

Background

CELF-1 is a highly conserved, ubiquitous protein which binds pre-mRNA in the nucleus to mediate alternative splicing to produce alternative transcripts in tissue-specific and developmentally regulated events. In the cytoplasm, CELF-1 binds to GRE-containing transcripts which are rapidly degraded.  Additionally, cytoplasmic CELF-1 binds to untranslated regions of transcripts for stability and translation efficiency. Many transcripts targeted by CELF-1 show rapid up-regulation leading to cellular activation or proliferation, while others show down-regulation.  CELF-1 has also been shown to localize to cytoplasmic stress granules when cells are stressed. This gene is associated with myotonic dystrophy type 1 (DM1) disease though interactions with the dystrophia myotnica-protein kinase (DMPK) gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.