Complement Component C3aR Antibody (534625) [Allophycocyanin]

• Applications: Flow
• Clone: 534625
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

Complement Component C3aR Antibody (534625) [Allophycocyanin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human C3a R
  Met1-Val482
  Accession # Q16581
• Specificity: Detects human Complement Component C3a R in direct ELISAs.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: C3AR1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Complement Component 3a receptor (C3a R) is a 70-80 kDa G-protein coupled 7-transmembrane sulfated glycoprotein that belongs to the G-protein coupled receptor 1 family of proteins. It is expressed inducibly or constitutively by platelets, eosinophils, monocytes, astrocytes, CD4⁺ T cells, dendritic cells, NK cells, mast cells and basophils, neutrophils, adipocytes, osteoclasts, osteoblasts macrophages, vascular endothelial cells, bronchial epithelium and smooth muscle. Engagement of C3a R by  77 kDa C3a has a number of effects that are context-dependent. C3a action on adipocytes facilitates glucose and fatty acid uptake, while in bone, C3a R (plus C5aR) drive the generation of Th1 and Th17 cells. Perhaps its best action is that of a mediator of anaphylaxis. On mast cells it induces histamine release, visceral smooth muscle contraction and vasodilation. Human C3a R extracellular regions share 50% and 42% amino acid identity with mouse and rat C3a R, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: C3AR1