CoCoA Antibody [HRP]

Product Discontinued

CoCoA Antibody [HRP] Summary

• Immunogen: Produced in rabbits immunized with E. coli-derived Human CoCoA fragment.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CALCOCO1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Alternate Names for CoCoA Antibody [HRP]

• calcium binding and coiled-coil domain 1
• calphoglin
• Cocoa
• Coiled-coil coactivator protein
• coiled-coil leucine zipper coactivator 1
• inorganic pyrophosphatase activator
• KIAA1536calcium-binding and coiled-coil domain-containing protein 1
• Sarcoma antigen NY-SAR-3

Background

HPS3 is involved in early stages of melanosome biogenesis and maturation. Defects in HPS3 are the cause of the cocoa (coa) mutant, and of Hermansky-Pudlak syndrome type 3 (HPS3). HPS3 is an autosomal recessive disorder, characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CALCOCO1