CLCA1 Antibody (1022517) [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: IHC
• Clone: 1022517
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

CLCA1 Antibody (1022517) [Alexa Fluor® 350] Summary

• Immunogen: Human embryonic kidney cell HEK293-derived CLCA1
  Asn22-Ser477
  Accession # A8K714
• Specificity: Detects CLCA1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CLCA1 Antibody (1022517) [Alexa Fluor® 350]

• CaCC
• CaCC-1
• Calcium-activated chloride channel family member 1
• Calcium-activated chloride channel protein 1
• chloride channel accessory 1
• chloride channel regulator 1
• chloride channel regulator
• chloride channel, calcium activated, family member 1
• CLCA1
• CLCRG1
• FLJ95147
• GOB5
• hCaCC-1
• HCLCA1

Background

CLCA1 is a member of the calcium sensitive chloride conductance protein family which may be involved in mediating calcium-activated chloride conductance.  This protein is expressed in goblet cells and intestinal basal crypt epithelial of the small intestine and colon. CLCA1 regulates mucin expression and participates in innate immune responses by binding to yet unidentified molecules on inflammatory cells for cytokine and chemokine production.  CLCA1 also targets lymphatic endothelial cells and cancer cells.  CLCA1 is a candidate as a modulating factor in the pathogenesis of mucus hypersecretory-associated respiratory and gastrointestinal diseases including asthma, COPD, cystic fibrosis, pneumonia, colon colitis, cystic fibrosis intestinal mucous disease, ulcerative colitis, and gastrointestinal parasitic infection.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.