CHD3 Recombinant Enzymes

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications NULL

Order Details

CHD3 Recombinant Enzymes Summary

Description
Human CHD3 (aa 1-2000) fused to 6xHis and FLAG-tag at the N-terminus. (Uniprot: Q12873-1)
Source
Sf 9 (baculovirus)
Protein/Peptide Type
Recombinant Enzymes
Gene
CHD3
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • N/A

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl, pH 7.9, 150 mM NaCl, 15% glycerol, 2 mM MgCl2, 0.2 mM EDTA, 1 mM DTT, 10 mM beta-glycerophospate, 0.4 mM PMSF, 1 mM benzamidine and 0.4 mg/ml recombinant human insulin
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for CHD3 Recombinant Enzymes

  • ATP-dependent helicase CHD3
  • CHD-3
  • chromodomain helicase DNA binding protein 3
  • chromodomain-helicase-DNA-binding protein 3
  • EC 3.6.1
  • EC 3.6.4.12
  • hZFH
  • Mi-2 autoantigen 240 kDa protein
  • Mi-2a
  • Mi2-ALPHA
  • ZFH
  • Zinc finger helicase
  • zinc-finger helicase (Snf2-like)

Background

CHD3 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD3 is a key component of the NuRD (nucleosomal remodeling) complex and directly interacts with histone deacetylases 1 and 2, ATR, and TRIM 27. Studies in several species suggest a role for CHD3 in the repression of developmental genes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol CHD3