CD79A Antibody (HM57) [PE]

Product Discontinued

CD79A Antibody (HM57) [PE] Summary

• Immunogen: Synthetic peptide corresponding to amino acids 202-216 of human CD79a
• Specificity: The antibody HM57 interacts with CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
  HLDA V; WS Code BC cB018
  HLDA VI; WS Code BP 193
  HLDA VI; WS Code BP 89
  HLDA VI; WS Code B B103
  HLDA VI; WS Code B CD79.4
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CD79A
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry

Reactivity Notes

Cross reacts with Human, Porcine, Mouse, Rat, Bovine, Equine, Guinea pig, Opossum, Rabbit and Chicken.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: Phosphate buffered saline (PBS), pH 7.4
• Preservative: 15mM Sodium Azide
• Purity: IgG purified

Notes

Store in the dark. Avoid prolonged exposure to light.

Alternate Names for CD79A Antibody (HM57) [PE]

• CD79A antigen (immunoglobulin-associated alpha)
• CD79a antigen
• CD79a molecule, immunoglobulin-associated alpha
• CD79A
• IGAB-cell antigen receptor complex-associated protein alpha chain
• ig-alpha
• MB-1 membrane glycoprotein
• MB1
• MB-1
• Membrane-bound immunoglobulin-associated protein
• Surface IgM-associated protein

Background

A disulfide-linked heterodimer, consisting of CD79a / mb1 and CD79b / B29 polypeptides, is non-covalently associated with membrane bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. The CD79a/b heterodimer interacts with at least one tyrosine kinase (Lyn). Induction of tyrosine kinase activity after antigen binding causes phosphorylation of the CD79a/b dimer, and also of other molecules, thereby initiating intracellular signaling.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CD79A