Cbl-c Antibody

Immunohistochemistry-Paraffin: Cbl-c Antibody [NBP1-02810] - Staining of human pancreas tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Discontinued

Cbl-c Antibody Summary

• Immunogen: Synthetic peptide corresponding to amino acids 444-458 of Human Cbl-c.
• Specificity: Amino acids 444-458 of Human Cbl-c.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CBLC
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000 - 1:50000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:500 - 1:3000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.2) and 0.15M NaCl
• Preservative: 0.01% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cbl-c Antibody

• Cas-Br-M (murine) ecotropic retroviral transforming sequence c
• Cas-Br-M (murine) ectropic retroviral transforming sequence c
• CBL3
• CBL-3
• CBL-SL
• RING finger protein 57
• RNF57SH3-binding protein CBL-3
• SH3-binding protein CBL-C
• signal transduction protein CBL-C

Background

Cbl-c is also known as signal transduction protein CBL-C, SH3-binding protein CBL-C, CBL-3, and RING finger protein 57. Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl-c (a.k.a. Cbl-3) is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Cbl-c knock out mice show no obvious phenotype. Thus, the physiological role of Cbl-c is not known

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CBLC
• Entrez:
  • 23624(Human)
• Uniprot:
  • Q9ULV8(Human)