Caspase-6 Antibody (6CSP01 (7.1.65))

Product Discontinued

Caspase-6 Antibody (6CSP01 (7.1.65)) Summary

• Immunogen: Recombinant human Caspase 6 prodomain.
• Epitope: Caspase 6 prodomain.
• Localization: Cytoplasmic.
• Specificity: Caspase 6 (6CSP01 (7.1.65))
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: CASP6
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 2ug/mg
  • Western Blot
• Application Notes: Immunoprecipitation (denatured verified, with protein G): use at a concentration of 2ug/mg of lysate. Not tested in any other applications. Optimal dilutions/concentrations should be determined by the end user.
• Control:

  Caspase-6 Overexpression Lysate

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM PBS (pH 7.4) and 0.2% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for Caspase-6 Antibody (6CSP01 (7.1.65))

• Apoptotic protease Mch-2
• CASP6
• CASP-6
• caspase 6, apoptosis-related cysteine peptidase
• caspase 6, apoptosis-related cysteine protease
• Caspase6
• Caspase-6
• EC 3.4.22
• Mch2
• MCH2EC 3.4.22.59

Background

Caspases play a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells, and are activated in response to distinct apoptosis inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase 6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CASP6
• Entrez:
  • 839(Human)