Calsenilin Antibody

Images

 
Western Blot: Calsenilin Antibody [NBP2-30049] - Western blot analysis of KChIP3 Antibody (N-term M1) (NBP2-30049) in mouse heart tissue lysates (35ug/lane). KChIP3(arrow) was detected using the purified Pab.
Immunocytochemistry/ Immunofluorescence: Calsenilin Antibody [NBP2-30049] - Confocal immunofluorescent analysis of KChIP3 Antibody (N-term M1) (NBP2-30049) with HepG2 cell followed by Alexa Fluor 488-conjugated goat ...read more
Immunohistochemistry-Paraffin: Calsenilin Antibody [NBP2-30049] - Formalin-fixed and paraffin-embedded human brain tissue reacted with KChIP3 Antibody (N-term M1) (NBP2-30049), which was peroxidase-conjugated to the ...read more
Immunohistochemistry-Paraffin: Calsenilin Antibody [NBP2-30049] - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ICC/IF, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
5 mg/ml

Order Details

Calsenilin Antibody Summary

Immunogen
This KChIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNIP3
Purity
Ammonium sulfate precipitation
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry-Paraffin 1:50 - 1:100
Theoretical MW
29.231 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
5 mg/ml
Purity
Ammonium sulfate precipitation

Alternate Names for Calsenilin Antibody

  • calsenilin
  • calsenilin, presenilin-binding protein, EF hand transcription factor
  • CSEN MGC18289
  • DREAM
  • DREAMA-type potassium channel modulatory protein 3
  • KCHIP3 DRE-antagonist modulator
  • KChIP3
  • Kv channel interacting protein 3, calsenilin
  • Kv channel-interacting protein 3
  • potassium channel interacting protein 3

Background

KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KCNIP3
Uniprot