Calsenilin Antibody (RB0527-0528)

Product Discontinued

Calsenilin Antibody (RB0527-0528) Summary

• Immunogen: This KChIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KChIP3.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNIP3
• Purity: Ammonium sulfate precipitation

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50 - 1:100
  • Western Blot 1:1000
• Theoretical MW: 29.231 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 5 mg/ml
• Purity: Ammonium sulfate precipitation

Alternate Names for Calsenilin Antibody (RB0527-0528)

• calsenilin
• calsenilin, presenilin-binding protein, EF hand transcription factor
• CSEN MGC18289
• DREAM
• DREAMA-type potassium channel modulatory protein 3
• KCHIP3 DRE-antagonist modulator
• KChIP3
• Kv channel interacting protein 3, calsenilin
• Kv channel-interacting protein 3
• potassium channel interacting protein 3

Background

KChIP3 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease. Due to utilization of an alternate in-frame translation start codon, the gene for this protein encodes two isoforms with different sizes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNIP3
• Uniprot:
  • Q9Y2W7(Human)