Calpain 9 Antibody (OTI3G10) [DyLight 650]

• Reactivity: Hu, Mu, Rt, Ca, Pm
• Applications: IHC
• Clone: OTI3G10
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

Calpain 9 Antibody (OTI3G10) [DyLight 650] Summary

• Immunogen: Full length recombinant protein of human Calpain 9 (NP_006606) produced in HEK293T cells.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: CAPN9
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Calpain 9 Antibody (OTI3G10) [DyLight 650]

• calpain 9 (nCL-4)
• calpain 9
• calpain-9
• Digestive tract-specific calpain
• EC 3.4.22
• EC 3.4.22.54
• GC36
• NCL4
• nCL-4EC 3.4.22.-
• New calpain 4
• novel calpain large subunit-4
• Protein CG36

Background

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CAPN9