beta-2 Adrenergic R/ADRB2 [p Thr384] Antibody

Product Discontinued

beta-2 Adrenergic R/ADRB2 [p Thr384] Antibody Summary

• Immunogen: synthetic peptide containing the sequence PGpTED in which pT corresponds to phosphothreonine at residue 384 of human beta 2-Adrenergic Receptor.
• Modification: p Thr384
• Specificity: phospho-beta 2-Adrenergic Receptor (Thr384).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADRB2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Theoretical MW: 43 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 0.1M Tris-Glycine (phH 7.4), 0.15M NaCl and 30% Glycerol
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Relevant Entrez Gene Numbers: NM_000024

Alternate Names for beta-2 Adrenergic R/ADRB2 [p Thr384] Antibody

• ADRB2
• ADRB2R
• ADRBR
• adrenergic, beta-2-, receptor, surface
• B2AR
• B2ARADRB2R
• BAR
• beta-2 Adrenergic R
• beta-2 adrenergic receptor
• beta2 AdrenergicR
• beta-2 AdrenergicR
• Beta-2 adrenoceptor
• Beta-2 adrenoreceptor
• BETA2AR
• catecholamine receptor

Background

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ADRB2
• Uniprot:
  • P35626()