BCAP/PIK3AP1 Antibody (501813) [Alexa Fluor® 405]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 501813
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

BCAP/PIK3AP1 Antibody (501813) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human BCAP
  Met462-Leu650
  Accession # Q6ZUJ8
• Specificity: Detects endogenous human and mouse BCAP in Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BCAP/PIK3AP1 Antibody (501813) [Alexa Fluor® 405]

• 1810044J04Rik
• B cell adaptor protein
• BCAP
• BCAPB-cell adapter for phosphoinositide 3-kinase
• B-cell phosphoinositide 3-kinase adapter protein 1
• FLJ35564
• phosphoinositide 3-kinase adapter protein 1
• phosphoinositide-3-kinase adaptor protein 1
• Pik3ap1
• RP11-34E5.3

Background

BCAP (B cell adaptor for phosphoinositide 3-kinase (PI3K)), also known as PI3KAP1, participates in linking the B cell antigen receptor (BCR) with the PI3K pathway. Tyrosine phosphorylation of BCAP by BCR-associated protein tyrosine kinases, such as Syk and Btk, generates binding sites for the p85 subunit of PI3K, resulting in activation of the PI3K pathway. Human and mouse BCAP contain 3 YXXM SH2 binding motifs for interaction with PI3K. BCAP null mice have deficient immune function, with B cells that exhibit enhanced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.