BACE-1 Antibody [Alexa Fluor™ Plus 405]

• Reactivity: Hu, Mu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 405

BACE-1 Antibody [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human and mouse BACE‑1 Ectodomain in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross‑reactivity with recombinant human (rh) ADAM8, recombinant mouse ADAM9, rhADAM15, and rhTACE is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BACE-1 Antibody [Alexa Fluor™ Plus 405]

• APP beta-secretase
• ASP2
• Aspartyl protease 2
• BACE1
• BACE-1
• BACEAsp 2
• beta-secretase 1 precursor variant 1
• beta-secretase 1
• beta-site amyloid beta A4 precursor protein-cleaving enzyme
• Beta-site amyloid precursor protein cleaving enzyme 1
• Beta-site APP cleaving enzyme 1
• beta-site APP-cleaving enzyme 1
• beta-site APP-cleaving enzyme
• EC 3.4.23
• EC 3.4.23.46
• FLJ90568
• HSPC104
• KIAA1149
• memapsin-2
• Membrane-associated aspartic protease 2
• transmembrane aspartic proteinase Asp2

Background

BACE-1 is an aspartic protease and an integral membrane protein (1 - 5). BACE-1 is the peptidase predominantly responsible for cleavage of the amyloid precursor protein beta site in the brain to generate the amyloid beta peptide. Because the amyloid beta peptide is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. BACE-1 is expressed in a variety of human tissues. It is likely that this peptidase has functions in addition to its hydrolysis of the amyloid precursor protein. The peptidase activity of BACE-1 is optimal under mildly acidic conditions (pH 3.5 - 5.5), consistent with its proposed function in an acidic intracellular compartment.

1. Ermolieff, J. et al. (2000) Biochemistry 39:12450.
2. Lin, X. et al. (2000) Proc. Natl. Acad. Sci. USA 97:1456.
3. Sinha, S. et al. (1999) Nature 402:537.
4. Vassar, R. et al. (1999) Science 286:735.
5. Yan, R. et al. (1999) Nature 402:533.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.