BACE-1 Products

Antibodies
BACE-1 Antibody
BACE-1 Antibody
NBP1-62416
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
BACE-1 Antibody (137612)
BACE-1 Antibody (137612)
MAB931
Species: Hu, Mu
Applications: WB, IHC, ICFlow
Host: Mouse Monoclonal
BACE-1 Antibody (137626)
BACE-1 Antibody (137626)
MAB9311
Species: Hu, Mu
Applications: IP, Neut
Host: Mouse Monoclonal
Kits
BACE-1 Assay Kit
BACE-1 Assay Kit
KA0900
Species: Ma
Applications: Func
Lysates
BACE-1 Overexpression Lysate ...
BACE-1 Overexpression Lysate (Native)
NBP2-04325
Applications: WB
BACE-1 Overexpression Lysate ...
BACE-1 Overexpression Lysate (Dena...
H00023621-T01
Applications: WB
Proteins
BACE-1 Recombinant Protein
BACE-1 Recombinant Protein
H00023621-P01
Species: Hu
Applications: WB, ELISA, PA
BACE-1 Peptide
BACE-1 Peptide
NBP1-77307PEP
Species: Hu
Applications: AC
BACE-1 Recombinant Protein
BACE-1 Recombinant Protein
NBP1-99279
Species: Hu
RNAi
BACE-1 RNAi
BACE-1 RNAi
H00023621-R01
Species: Hu
BACE-1 RNAi
BACE-1 RNAi
H00023621-R02
Species: Hu
BACE-1 RNAi
BACE-1 RNAi
H00023621-R04
Species: Hu

Description

BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 23621
Alternate Names
  • FLJ90568
  • EC 3.4.23
  • beta-site APP-cleaving enzyme
  • Memapsin-2
  • EC 3.4.23.46
  • transmembrane aspartic proteinase Asp2
  • KIAA1149
  • memapsin-2
  • ASP2
  • beta-site amyloid beta A4 precursor protein-cleaving enzyme
  • Membrane-associated aspartic protease 2
  • beta-secretase 1 precursor variant 1
  • Beta-site APP cleaving enzyme 1
  • beta-secretase 1
  • Beta-site amyloid precursor protein cleaving enzyme 1
  • APP beta-secretase
  • Aspartyl protease 2
  • BACEAsp 2
  • HSPC104
  • beta-site APP-cleaving enzyme 1

Research Areas for BACE-1

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration
Neuroscience
Phospho-Specific

Bioinformatics Tool for BACE-1

Discover related pathways, diseases and genes to BACE-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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