AMPD1 Antibody

Product Discontinued

AMPD1 Antibody Summary

• Immunogen: Peptide with sequence C-HMFSSKSPKPQE corresponding to internal region according to NP_000027.1.
• Epitope: C-HMFSSKSPKPQE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: AMPD1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:1000
• Application Notes: WB: Preliminary experiments in human muscle and rat muscle lysates gave no specific signal but low background.
• Control:

  AMPD1 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for AMPD1 Antibody

• adenosine monophosphate deaminase 1 (isoform M)
• adenosine monophosphate deaminase 1
• adenosine monophosphate deaminase-1 (muscle)
• AMP deaminase 1
• AMP deaminase isoform M
• AMPD
• EC 3.5.4.6
• MAD
• MADA
• Myoadenylate deaminase
• skeletal muscle AMPD

Background

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for AMPD1 Antibody (NB100-93371)(1)

Publication using NB100-93371

• Hand BD, Roth SM, Roltsch MH et al. AMPD1 gene polymorphism and the vasodilatory response to ischemia. Life Sci 2006-09-05 [PMID: 16707139]

Bioinformatics

• Gene Symbol: AMPD1
• Entrez:
  • 270(Human)
  • 229665(Mouse)
  • 25028(Rat)
• Uniprot:
  • NP_000027.1(Human)