alpha-Aminoadipate Aminotransferase Antibody

Product Discontinued

alpha-Aminoadipate Aminotransferase Antibody Summary

• Immunogen: AADAT (NP_057312, 326 a.a. ~ 426 a.a) partial recombinant protein with GST tag.YSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKVKGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQLIKESL
• Specificity: AADAT - aminoadipate aminotransferase
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: AADAT
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot 1:500
• Application Notes: The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500

Reactivity Notes

Avian reactivity reported in scientific literature (PMID: 23761975)

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol
• Preservative: No Preservative
• Purity: Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for alpha-Aminoadipate Aminotransferase Antibody

• AADAT
• alphaAminoadipate Aminotransferase
• alpha-Aminoadipate Aminotransferase
• aminoadipate aminotransferase
• EC 2.6.1.39,2-aminoadipate aminotransferase
• EC 2.6.1.7,2-aminoadipate transaminase
• KAT/AadAT
• KAT2
• KAT2mitochondrial
• Kynurenine aminotransferase II
• Kynurenine--oxoglutarate aminotransferase II
• Kynurenine--oxoglutarate transaminase II
• L kynurenine/alpha aminoadipate aminotransferase

Background

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for alpha-Aminoadipate Aminotransferase Antibody (H00051166-A01)(2)

Publications using H00051166-A01

• Lim CK, Yap MM, Kent SJ et al. Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages. Int J Tryptophan Res. 2013-01-01 [PMID: 23761975] (Avian)
• Guillemin GJ, Cullen KM, Lim CK et al. Characterization of the Kynurenine Pathway in Human Neurons. J Neurosci 2007-11-21 [PMID: 18032661]

Bioinformatics

• Gene Symbol: AADAT
• Entrez:
  • 51166(Human)
• Uniprot:
  • NP_057312(Human)