Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody

Product Discontinued

Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody Summary

• Immunogen: Peptide with sequence C-HNNYKSATHEND corresponding to internal region according to NP_004253.1.
• Epitope: C-HNNYKSATHEND
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TMPRSS11D
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: Preliminary experiments gave an approx. 20 kDa band in lysates of HepG2 after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 46.3 kDa band according to NP_004253.1. The 20 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody

• airway trypsin like protease
• Airway trypsin-like protease
• EC 3.4.21
• EC 3.4.21.-
• HAT
• MGC150587
• MGC150588
• TMPRSS11D
• transmembrane protease serine 11D
• transmembrane protease, serine 11D

Background

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Airway Trypsin-like Protease/HAT/TMPRSS11D Antibody (NBP1-52138)(1)

Publication using NBP1-52138

• Bottcher E, Matrosovich T, Beyerle M et al. Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. J Virol 2006-10-01 [PMID: 16973594]

Bioinformatics

• Gene Symbol: TMPRSS11D
• Entrez:
  • 9407(Human)
• Uniprot:
  • NP_004253.1()