Adenylate Cyclase 3 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

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Catalog# & Conjugate Size Price

Adenylate Cyclase 3 Antibody [FITC] Summary

Immunogen
A 20 amino acid peptide corresponding to the C-terminus of rat Adenylate Cyclase 3. [UniProt# P21932]
Localization
Membrane; Multi-pass membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ADCY3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence
Application Notes
This Adenylate Cyclase 3 antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where bands can be seen at 160-200 kDa (depending on the tissue). In WB, bands can be seen at about 200kDa in olfactory epithelium which is rich in cilia. Fewer cilia are found in frontal cortex, and the protein is less heavily glycosylated, and a less prominent band is seen at about 160kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
129 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and rat.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Adenylate Cyclase 3 Antibody [FITC]

  • AC3EC 4.6.1.1
  • AC-III
  • adenylate cyclase 3
  • adenylate cyclase type 3
  • Adenylate cyclase type III
  • Adenylyl cyclase 3
  • adenylyl cyclase, type III
  • ATP pyrophosphate-lyase 3
  • EC 4.6.1
  • KIAA0511
  • olfactive type

Background

The biosynthesis of cAMP/cyclic 3'5'-AMP from ATP is catalyzed by adenylyl cyclases (ADCYs or ACs) which are a groups of enzymes having about ten closely related isoforms including ADCYs 1-9 and ADCYAP1 (ADCY activating polypeptide 1). Adenylate Cyclase 3 (ADCY3 or AC3) is third member of ADCYs family which is a membrane-associated enzyme and catalyzes the formation of secondary messenger cAMP. ADCY3 enzyme is localized in the membranes surrounding cilia in neurons, and is considered an excellent marker of neuronal cilia in brain tissues or in cell culture. Human ADCY3 is a large complex molecule of 1145 amino acids with an expected molecular weight of 129kD and due to extensive glycosylation, a diffused band of about 160kD in cortex and about 200kD in olfactory epithelium is generally observed in Western blots. ADCY3 appears to be widely expressed in various human tissues wherein it implicates in a number of physiological (including odorant detection via controlling intracellular cAMP levels) as well as pathophysiological metabolic processes. ADCY3 knock out mice exhibits obesity upon ageing primarily because of low locomoter activity, hyperphagia and leptin insensitivity. Moreover, ADCY3 genetic polymorphisms have been linked to decreased risk of body mass index/BMI among the subjects with obesity and type 2 diabetes/NIDDM suggesting that ADCY3 is a novel candidate in the regulation of body weight.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Diseases for Adenylate Cyclase 3 Antibody (NBP1-92683F)

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Bioinformatics

Gene Symbol ADCY3