ADAMTS8 Antibody

Product Discontinued

ADAMTS8 Antibody Summary

• Immunogen: Peptide with sequence C-RQERGDHQED corresponding to internal region according to NP_008968.4.
• Epitope: C-RQERGDHQED
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: ADAMTS8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:4000
• Application Notes: WB: Preliminary experiments in human brain (cerebellum), heart, kidney, lung, skeletal muscle and placenta lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for ADAMTS8 Antibody

• a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 8
• ADAM metallopeptidase with thrombospondin type 1 motif, 8
• ADAMTS8
• ADAMTS-8
• ADAM-TS8A disintegrin and metalloproteinase with thrombospondin motifs 8
• EC 3.4.24
• EC 3.4.24.-
• EC 3.4.24.14
• EC 3.4.24.82
• FLJ41712
• METH-2
• METH2ADAM-TS 8
• METH-8

Background

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ADAMTS8 Antibody (NBP1-52159)(1)

Publication using NBP1-52159

• WagsaterD, Bjork H, Zhu C et al. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Atherosclerosis 2008-02-01 [PMID: 17606262]

Bioinformatics

• Gene Symbol: ADAMTS8
• Entrez:
  • 11095(Human)
• Uniprot:
  • NP_008968.4(Human)