Species: Hu, Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Mu, Rt
Applications: ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Sheep Polyclonal
Species: Hu
Applications: AC
Description
DISC1 (Disrupted in Schizophrenia 1) is a well known risk genes for psychiatric disorders including schizophrenia, major depression, bipolar disorder, and autism. DISC1 protein localize to cytoskeleton-rich regions in cells, including the centrosome, base of primary cilia, axon and dendritic shafts and spines. For serving its multiple functions, DISC1 interacts with CCDC88A, GSK3B, PCNT, tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1, TRAF3IP1, CHCHD6 and NDEL1. DISC1 interaction with microtubules TRAF3IP1. In neurogenesis regulation, DISC1 is essential for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development as well as in adult dentate gyrus of hippocampus. DISC1 modulates GSK3Beta activity and CTNNB1 abundance for acting as positive regulator of WNT-mediated neural progenitor proliferation. DISC1 can modulate AKT-mTOR signaling for controlling the neuron positioning, dendritic development and synapse formation which ultimately regulate newborn neurons integration during adult neurogenesis and can regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Moreover, DISC1 is implicated in microtubule network formation, regulation of functional biology of centrosome as well as primary cilia, neuronal migration and microtubule mediated transport.
Bioinformatics
| Product By Gene ID |
27185 |
| Alternate Names |
- C1orf136
- DISC1
- disrupted in schizophrenia 1 protein
- disrupted in schizophrenia 1
- FLJ13381
- FLJ21640
- FLJ25311
- FLJ41105
- KIAA0457
- SCZD9
|
