Sonic Hedgehog/Shh Products

Antibodies
Sonic Hedgehog/Shh Antibody
Sonic Hedgehog/Shh Antibody
NBP2-22139
Species: Hu, Mu, Rt, Pm, Chicken, Xenopus, Zebrafish
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Sonic Hedgehog/Shh Antibody [ ...
Sonic Hedgehog/Shh Antibody [Uncon...
AF464
Species: Hu, Mu
Applications: WB, IHC
Host: Goat Polyclonal
Sonic Hedgehog/Shh Antibody ( ...
Sonic Hedgehog/Shh Antibody (5H4)
NBP2-22126
Species: Hu, Mu, Pm
Applications: WB, ELISA, Flow, IHC-P
Host: Mouse Monoclonal
ELISA Kits
Sonic Hedgehog/Shh ELISA Kit ...
Sonic Hedgehog/Shh ELISA Kit [HRP]
KA2144
Species: Hu
Lysates
Sonic Hedgehog/Shh Overexpres ...
Sonic Hedgehog/Shh Overexpression ...
NBL1-15941
Applications: WB
Proteins
Mouse Sonic Hedgehog/Shh Prot ...
Mouse Sonic Hedgehog/Shh Protein
NBP2-35174
Species: Mu
Applications: Func, PAGE
Human Sonic Hedgehog/Shh Prot ...
Human Sonic Hedgehog/Shh Protein
NBP2-35265
Species: Hu
Applications: Func, PAGE
Mouse Sonic Hedgehog/Shh Biol ...
Mouse Sonic Hedgehog/Shh Biologica...
NBP2-35339
Species: Mu
Applications: Func, PAGE
RNAi
Sonic Hedgehog/Shh RNAi
Sonic Hedgehog/Shh RNAi
H00006469-R01
Species: Hu

Description

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal (1). Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene (2). Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo (3). A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 6469
Alternate Names
  • HLP3
  • HHG-1
  • TPTPS
  • sonic hedgehog protein
  • TPT
  • sonic hedgehog homolog
  • HHG1
  • SMMCIsonic hedgehog homolog (Drosophila)
  • MCOPCB5sonic hedgehog (Drosophila) homolog
  • HPE3
  • sonic hedgehog

Research Areas for Sonic Hedgehog/Shh

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems
Stem Cell Signaling Pathway
Vision

Bioinformatics Tool for Sonic Hedgehog/Shh

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