Sonic Hedgehog/Shh Products

Antibodies
ELISA Kits
Mouse Sonic Hedgehog/Shh DuoS ...
Mouse Sonic Hedgehog/Shh DuoSet EL...
DY461
Species: Mu
Applications: ELISA
Human Sonic Hedgehog/Shh N-Te ...
Human Sonic Hedgehog/Shh N-Terminu...
DSHH00
Species: Hu
Applications: ELISA
Mouse Sonic Hedgehog/Shh N-Te ...
Mouse Sonic Hedgehog/Shh N-Terminu...
MSHH00
Species: Mu
Applications: ELISA
Lysates
Sonic Hedgehog/Shh Overexpres ...
Sonic Hedgehog/Shh Overexpression ...
NBL1-15941
Applications: WB
Proteins
Recombinant Human Sonic Hedge ...
Recombinant Human Sonic Hedgehog/S...
1845-SH
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse Sonic Hedge ...
Recombinant Mouse Sonic Hedgehog/S...
464-SH
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Mouse Sonic Hedge ...
Recombinant Mouse Sonic Hedgehog/S...
461-SH
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Sonic Hedgehog Protein (SHH, VHH-1) belongs to hedgehog protein family which includes Indian Hh, and Desert Hh. Hh family is involved in the cell fate and patterning during embryonic development, homeostasis, and adult tissue renewal (1). Similar to other member in the family, SHH binds to the patched (PTC) cell surface receptor, releasing the signal transducer Smoothened (Smo) to transmit the Hh signal into the cell and activate transcription of the target gene (2). Precursor SHH is autocatlytically cleaved into two subunits, N-terminal and C-terminal products. Soluble N-terminal product is involved in the signaling activity, while C-product displays an autoproteolysis activity on the precursor and a cholesterol transferase activity on the N-terminal product. C-terminal product attaches a cholesterol moiety to the N-terminal product, preventing N-terminal product diffusion within the developing embryo (3). A defect in SHH has been linked in holoprosencephaly type 3 (HPE3), in which developing forebrain fails to separate into right and left hemispheres, and ocular coloboma (4).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Mouse
Product By Gene ID 6469
Alternate Names
  • HLP3
  • HHG-1
  • TPTPS
  • sonic hedgehog protein
  • TPT
  • sonic hedgehog homolog
  • HHG1
  • SMMCIsonic hedgehog homolog (Drosophila)
  • MCOPCB5sonic hedgehog (Drosophila) homolog
  • HPE3
  • sonic hedgehog

Research Areas for Sonic Hedgehog/Shh

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Sensory Systems
Stem Cell Signaling Pathway
Vision

Bioinformatics Tool for Sonic Hedgehog/Shh

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