JNK2 Products

Antibodies
JNK2 Antibody (252320) [Uncon ...
JNK2 Antibody (252320) [Unconjugated]
MAB1846
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Mouse Monoclonal
JNK2 Antibody (1A1)
JNK2 Antibody (1A1)
NBP2-45815
Species: Hu, Mu, Rt, Ca, Mk
Applications: WB, IHC, IF
Host: Mouse monoclonal
JNK2 Antibody
JNK2 Antibody
AF1846
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
JNK2 Overexpression Lysate (N ...
JNK2 Overexpression Lysate (Native)
NBL1-12885
Applications: WB
JNK2 Overexpression Lysate (N ...
JNK2 Overexpression Lysate (Native)
NBP2-05606
Applications: WB
JNK2 Overexpression Lysate (N ...
JNK2 Overexpression Lysate (Native)
NBP2-05607
Applications: WB
Proteins
Recombinant Human JNK2 Protei ...
Recombinant Human JNK2 Protein
NBP1-98883
Species: Hu
Applications: PAGE
RNAi
JNK2 RNAi
JNK2 RNAi
H00005601-R01V
Species: Hu
Applications: WB, RNAi, RNAi SP
JNK2 RNAi
JNK2 RNAi
H00005601-R08
Species: Hu
Applications: RNAi, RNAi SP
JNK2 RNAi
JNK2 RNAi
H00005601-R07
Species: Hu
Applications: RNAi, RNAi SP

Description

JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 5601
Alternate Names
  • EC 2.7.11.24
  • EC 2.7.11
  • MAPK 9
  • p54aSAPK
  • MAP kinase 9
  • Jun kinase
  • c-Jun N-terminal kinase 2
  • c-Jun kinase 2
  • JNK-55
  • Stress-activated protein kinase JNK2
  • p54a
  • JNK2BETA
  • SAPK
  • PRKM9JNK2B
  • JNK2JNK2ALPHA
  • JNK2A
  • mitogen-activated protein kinase 9

Research Areas for JNK2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Immunology
Innate Immunity
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway

PTMs for JNK2

Learn more about PTMs related to JNK2.

Phosphorylation

Bioinformatics Tool for JNK2

Discover related pathways, diseases and genes to JNK2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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