JNK2 Products

Antibodies
JNK2 Antibody (252320) [Uncon ...
JNK2 Antibody (252320) [Unconjugated]
MAB1846
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
JNK2 Antibody
JNK2 Antibody
NBP1-30905
Species: Hu, Mu, Rt, I, Ch
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
ELISA Kits
Phospho-JNK2 (T183/Y185) DuoS ...
Phospho-JNK2 (T183/Y185) DuoSet IC...
DYC2236-2
Species: Hu, Mu, Rt
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
JNK2 Overexpression Lysate
JNK2 Overexpression Lysate
NBP2-05607
Species: Hu
Applications: WB
JNK2 Overexpression Lysate
JNK2 Overexpression Lysate
NBL1-12886
Species: Hu
Applications: WB
JNK2 Overexpression Lysate
JNK2 Overexpression Lysate
NBL1-12885
Species: Hu
Applications: WB
Proteins
Recombinant Human JNK2 His Pr ...
Recombinant Human JNK2 His Protein
NBP1-98883
Species: Hu
Applications: PAGE

Description

JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3).

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Alternate Names
  • c-Jun kinase 2
  • c-Jun N-terminal kinase 2
  • EC 2.7.11
  • EC 2.7.11.24
  • JNK2A
  • JNK2BETA
  • JNK2JNK2ALPHA
  • JNK-55
  • Jun kinase
  • MAP kinase 9
  • MAPK 9
  • mitogen-activated protein kinase 9
  • p54a
  • p54aSAPK
  • PRKM9JNK2B
  • SAPK
  • Stress-activated protein kinase JNK2

Research Areas for JNK2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Immunology
Innate Immunity
Phospho-Specific
Protein Kinase
Signal Transduction
Wnt Signaling Pathway