Species: Hu, Mu, Rt, Ca, Ha
Applications: WB, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE, Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share approx. 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90- binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).
Bioinformatics
| Product By Gene ID |
2288 |
| Alternate Names |
- 51 kDa FK506-binding protein
- 52 kDa FKBP
- 59 kDa immunophilin
- EC 5.2.1.8
- FK506 binding protein 4, 59kDa
- FK506-binding protein 4 (59kD)
- FK506-binding protein 4
- FKBP4
- FKBP-4
- FKBP51
- FKBP52
- FKBP-52
- FKBP52T-cell FK506-binding protein, 59kD
- FKBP59
- FKBP5952 kDa FK506-binding protein
- HBI
- HSP binding immunophilin
- Hsp56
- HSP-binding immunophilin
- Immunophilin FKBP52
- p52
- p59
- peptidyl-prolyl cis-trans isomerase FKBP4
- peptidylprolyl cis-trans isomerase
- PPIase FKBP4
- PPIase
- Rotamase
|
