FKBP52/FKBP4 Products

Antibodies
FKBP52/FKBP4 Antibody (5C11)
FKBP52/FKBP4 Antibody (5C11)
H00002288-M01
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IP
Host: Mouse Monoclonal
FKBP52/FKBP4 Antibody
FKBP52/FKBP4 Antibody
NBP1-84675
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
FKBP52/FKBP4 Antibody
FKBP52/FKBP4 Antibody
NBP1-33702
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Antibody Pairs
FKBP52/FKBP4 Antibody Pair
FKBP52/FKBP4 Antibody Pair
H00002288-AP21
Species: Hu
Applications: S-ELISA
FKBP52/FKBP4 Antibody Pair
FKBP52/FKBP4 Antibody Pair
H00002288-AP31
Species: Hu
Applications: S-ELISA
FKBP52/FKBP4 Antibody Pair
FKBP52/FKBP4 Antibody Pair
H00002288-AP22
Species: Hu
Applications: S-ELISA
Lysates
FKBP52/FKBP4 Overexpression L ...
FKBP52/FKBP4 Overexpression Lysate...
H00002288-T01
Species: Hu
Applications: WB
FKBP52/FKBP4 Overexpression L ...
FKBP52/FKBP4 Overexpression Lysate...
NBL1-10738
Applications: WB
Proteins
FKBP52/FKBP4 Recombinant Prot ...
FKBP52/FKBP4 Recombinant Protein
NBC1-22936
Species: Hu
Applications: PAGE
Host: Human
FKBP52/FKBP4 Recombinant Prot ...
FKBP52/FKBP4 Recombinant Protein
H00002288-P01
Species: Hu
Applications: WB, ELISA, PA
FKBP52/FKBP4 Partial Recombin ...
FKBP52/FKBP4 Partial Recombinant P...
H00002288-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
FKBP52/FKBP4 RNAi
FKBP52/FKBP4 RNAi
H00002288-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share approx. 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90- binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 2288
Alternate Names
  • peptidylprolyl cis-trans isomerase
  • PPIase FKBP4
  • peptidyl-prolyl cis-trans isomerase FKBP4
  • p59
  • p52
  • Immunophilin FKBP52
  • HSP binding immunophilin
  • HSP-binding immunophilin
  • PPIase
  • FK506-binding protein 4
  • Hsp56
  • Rotamase
  • EC 5.2.1.8
  • FKBP-52
  • HBI
  • FKBP-4
  • FKBP51
  • 59 kDa immunophilin
  • 51 kDa FK506-binding protein
  • 52 kDa FKBP
  • FK506-binding protein 4 (59kD)
  • FKBP5952 kDa FK506-binding protein
  • FKBP52T-cell FK506-binding protein, 59kD
  • rotamase
  • FK506 binding protein 4, 59kDa

Research Areas for FKBP52/FKBP4

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Stem Cell Markers

PTMs for FKBP52/FKBP4

Learn more about PTMs related to FKBP52/FKBP4.

Methylation
Oxidation
Phosphorylation

Bioinformatics Tool for FKBP52/FKBP4

Discover related pathways, diseases and genes to FKBP52/FKBP4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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