FKBP52/FKBP4 Products

Description

Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones (1). One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin Abinding families of immunophilins (2). FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex (3). The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 (4). Although FKBP52 and FKBP51 share approx. 75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90- binding characteristics (3, 5). Also, whereas FKBP51 typically has a role with the progesterone receptor, FKBP52 has been found to be linked to the progesterone, androgen and glucocorticoid receptors (5).

Bioinformatics

Entrez	14228 Mouse 2288 Human 260321 Rat
Uniprot	AAH07924 Human NM_002014 Human NP_002005 Human NP_002005.1 Human Q02790 Human
Product By Gene ID	2288
Alternate Names	51 kDa FK506-binding protein 52 kDa FKBP 59 kDa immunophilin EC 5.2.1.8 FK506 binding protein 4, 59kDa FK506-binding protein 4 (59kD) FK506-binding protein 4 FKBP-4 FKBP51 FKBP-52 FKBP52T-cell FK506-binding protein, 59kD FKBP5952 kDa FK506-binding protein HBI HSP binding immunophilin Hsp56 HSP-binding immunophilin Immunophilin FKBP52 p52 p59 peptidyl-prolyl cis-trans isomerase FKBP4 peptidylprolyl cis-trans isomerase PPIase FKBP4 PPIase Rotamase rotamase

Research Areas for FKBP52/FKBP4

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Stem Cell Markers