eRF1 Products

Description

Termination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. The process of translation termination is universal and is mediated by protein release factors (RFs) and GTP. A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome. Class 2 RFs, which are not codon specific and do not recognize codons, stimulate class 1 RF activity and confer GTP dependency upon the process. In prokaryotes, both class 1 RFs, RF1 and RF2, recognize UAA; however, UAG and UGA are decoded specifically by RF1 and RF2, respectively. In eukaryotes, eRF1, or ETF1, the functional counterpart of RF1 and RF2, functions as an omnipotent RF, decoding all 3 stop codons (Frolova et al., 1994 [PubMed 7990965]).[supplied by OMIM]

Bioinformatics

Entrez	2107 Human
Uniprot	NM_004730 Human NP_004721 Human NP_004721.1 Human P62495 Human
Product By Gene ID	2107
Alternate Names	D5S1995 ERF1eRF1 eukaryotic peptide chain release factor subunit 1 Eukaryotic release factor 1 eukaryotic translation termination factor 1 polypeptide chain release factor 1 Protein Cl1 RF1ERF sup45 (yeast omnipotent suppressor 45) homolog-like 1 SUP45L1 TB3-1MGC111066