CNTF Products

Antibodies
CNTF Antibody
CNTF Antibody
AF-257-NA
Species: Hu
Applications: WB, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
CNTF Antibody [Unconjugated]
CNTF Antibody [Unconjugated]
AF-557-NA
Species: Rt
Applications: WB, IHC, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
CNTF Antibody
CNTF Antibody
AB-557-NA
Species: Rt
Applications: WB, IHC, Neut
Host: Goat Polyclonal
Antibody Pairs
CNTF Antibody Pair
CNTF Antibody Pair
H00001270-AP22
Species: Hu
Applications: S-ELISA
CNTF Antibody Pair
CNTF Antibody Pair
H00001270-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
CNTF ELISA Kit [Biotin]
CNTF ELISA Kit [Biotin]
KA1824
Species: Rt
CNTF ELISA Kit [Biotin]
CNTF ELISA Kit [Biotin]
KA1703
Species: Hu
Lysates
CNTF Overexpression Lysate (D ...
CNTF Overexpression Lysate (Denatu...
H00001270-T01
Species: Hu
Applications: WB
CNTF Overexpression Lysate (N ...
CNTF Overexpression Lysate (Native)
NBP2-09006
Applications: WB
Proteins
Rat CNTF Protein
Rat CNTF Protein
NBP2-35289
Species: Rt
Applications: Func, PAGE
Mouse CNTF Protein
Mouse CNTF Protein
NBP2-35168
Species: Mu
Applications: Func, PAGE
Human CNTF Protein
Human CNTF Protein
NBP2-34939
Species: Hu
Applications: Func, PAGE

Description

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 1270
Alternate Names
  • HCNTF
  • ciliary neurotrophic factor

Research Areas for CNTF

Find related products by research area and learn more about each of the different research areas below.

Neuroscience

Bioinformatics Tool for CNTF

Discover related pathways, diseases and genes to CNTF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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