CNTF Products

Antibodies
CNTF Antibody [Unconjugated]
CNTF Antibody [Unconjugated]
AF-557-NA
Species: Mu, Rt
Applications: IHC, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
CNTF Antibody
CNTF Antibody
AF-257-NA
Species: Hu
Applications: WB, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
CNTF Antibody
CNTF Antibody
AB-557-NA
Species: Rt
Applications: WB, IHC, B/N
Host: Goat Polyclonal
ELISA Kits
Mouse CNTF ELISA Kit (Chemilu ...
Mouse CNTF ELISA Kit (Chemilumines...
NBP2-75796
Species: Mu
Applications: ELISA
Mouse CNTF ELISA Kit (Colorim ...
Mouse CNTF ELISA Kit (Colorimetric)
NBP2-75797
Species: Mu
Applications: ELISA
Rat CNTF ELISA Kit (Chemilumi ...
Rat CNTF ELISA Kit (Chemiluminesce...
NBP2-67250
Species: Rt
Applications: ELISA
Lysates
CNTF Overexpression Lysate
CNTF Overexpression Lysate
NBP2-09006
Species: Hu
Applications: WB
Proteins
Recombinant Human CNTF Protei ...
Recombinant Human CNTF Protein
257-NT
Species: Hu
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Rat CNTF Protein
Recombinant Rat CNTF Protein
557-NT
Species: Rt
Applications: Bioactivity
Formulation Catalog # Availability Price  
Recombinant Rat CNTF Protein
Recombinant Rat CNTF Protein
NBP2-35289
Species: Rt
Applications: Func, PAGE, Bioactivity

Description

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS). As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 1270
Alternate Names
  • HCNTF
  • ciliary neurotrophic factor

Research Areas for CNTF

Find related products by research area and learn more about each of the different research areas below.

Neuroscience

Bioinformatics Tool for CNTF

Discover related pathways, diseases and genes to CNTF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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