Caspase-10/FLICE2 Products

Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Human Caspase-10/FLICE2 ELISA ...
Human Caspase-10/FLICE2 ELISA Kit ...
Species: Hu
Applications: ELISA
Rat Caspase-10/FLICE2 ELISA K ...
Rat Caspase-10/FLICE2 ELISA Kit (C...
Species: Rt
Applications: ELISA
Mouse Caspase-10/FLICE2 ELISA ...
Mouse Caspase-10/FLICE2 ELISA Kit ...
Species: Mu
Applications: ELISA
Caspase-10/FLICE2 Activity As ...
Caspase-10/FLICE2 Activity Assay K...
Species: Hu, Mu, Rt, Ma
Caspase-10/FLICE2 Assay Kit ( ...
Caspase-10/FLICE2 Assay Kit (Fluor...
Species: Hu, Mu, Rt, Ma
Recombinant Human Caspase-10 ...
Recombinant Human Caspase-10 (Mch ...
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Caspase-10/FLICE2 Recombinant ...
Caspase-10/FLICE2 Recombinant Prot...
Species: Hu
Applications: AC


Apoptosis, or programmed cell death, is a common property of all multicellular organisms. The current dogma of apoptosis suggests that the components of the core cell-death machinery are integral to cells and widely conserved across species. Caspases, a family of cysteinyl aspartate-specific proteases, are integral components of the cell death machinery (reviewed in Siegal, 2006; and Lavrik et al, 2005). They play a central role in the initiation and execution of apoptotic cell death and in inflammation. Caspases are typically divided into 3 major groups, depending on the structure of their prodomain and their function. Group 1: inflammatory caspases (caspases 1, 4, 5, 11, 12, 14). Group II: initiator of apoptosis caspases (caspases 2, 8, 9). Group II: effector caspases (caspases 3, 6, 7). Caspases are constitutively expressed in almost all cell types as inactive proenzymes (zymogens: enzyme precursors which require a biochemical change to become active enzymes) that are processed and activated in response to a variety of pro-apoptotic or inflammatory stimuli. The procaspases (32-56 kDa) contain four domains: an N-terminal prodomain (2-25 kDa), a large subunit (p20: 17-21 kDa), a small subunit (p10: 10-13 kDa) and a short linker region between the large and small subunits. Caspase activation involves proteolytic processing of the proenzyme at specific aspartate residues between the domains. This results in removal of the prodomain as well as the linker region and formation of a heterodimer containing one large and one small subunit (p20-p10). The active caspase is a tetramer composed of two heterodimers (p202-p102). Active caspases mediate cell death and inflammation through cleavage of particular cellular substrates that are involved in these processes. Caspase-10 is a 455 amino acid protein. However, caspase-10 produces, by alternative splicing, at least 12 different transcripts, all with introns, putatively encoding at least 11 different protein isoforms. For example, human caspase-10a is a 479 amino acid (aa) protein, and human caspase-10d is a 522 aa protein. The transcripts appear to differ by truncation of the end, presence or absence of 6 cassette exons, or common exons with different boundaries, because an internal intron is not always spliced out. Users are encoraged to go to the NCBI ACE View Data Base for more information. Caspase-10 gene mutations or polymorphisms have been associated with a number of diseases including type II autoimmune lymphoproliferative syndrome, non-Hiodgkin's lymphoma, and gastric cancer. It is thought that some mutations of the caspase-10 gene may lead to the loss of its apoptotic function, thereby contributing to the pathogenesis of some diseases. Caspase-10 may be observed on Western blots at varying apparent molecular weights depending on isoform, truncation, or cleavage forms present. Recognizes caspase-10 forms that contain the peptide immunogen sequence (QPAFTLRKKLVFPVPLDALSI).


Entrez Human
Uniprot Human
Product By Gene ID 843
Alternate Names
  • EC
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
  • interleukin-1B-converting enzyme 2
  • FLICE2
  • FADD-like ICE2
  • CASP-10
  • caspase-10
  • Apoptotic protease Mch-4
  • caspase 10, apoptosis-related cysteine protease
  • ICE-like apoptotic protease 4
  • caspase 10, apoptosis-related cysteine peptidase

Research Areas for Caspase-10/FLICE2

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Breast Cancer

PTMs for Caspase-10/FLICE2

Learn more about PTMs related to Caspase-10/FLICE2.


Bioinformatics Tool for Caspase-10/FLICE2

Discover related pathways, diseases and genes to Caspase-10/FLICE2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related Caspase-10/FLICE2 Blog Posts

Check out the latest blog posts on Caspase-10/FLICE2.
Caspase 10 - an initiator caspase in the extrinsic death receptor pathway
Apoptosis, also called programmed cell death, is an essential process in development and disease. The signaling networks that carry out apoptosis is consists of a series of endoproteases called caspases which are synthesized as inactive zymogens....    Read more.
Read more Caspase-10/FLICE2 related blogs.