Caspase-10/FLICE2 Products

Antibodies
Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
NB100-56123
Species: Hu, Mu, Rt, Ca
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
NB100-56125
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Caspase-10/FLICE2 Antibody
Caspase-10/FLICE2 Antibody
NB100-56124
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Kits
Caspase-10/FLICE2 Colorimetri ...
Caspase-10/FLICE2 Colorimetric Ass...
KA0730
Species: Ma
Applications: Func
Caspase-10/FLICE2 Fluorometri ...
Caspase-10/FLICE2 Fluorometric Ass...
KA0731
Species: Ma
Applications: Func
Caspase-10/FLICE2 Fluorometri ...
Caspase-10/FLICE2 Fluorometric Ass...
KA0732
Species: Ma
Applications: Func
Proteins
Recombinant Human Caspase-10/ ...
Recombinant Human Caspase-10/FLICE...
H00000843-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Caspase-10/ ...
Recombinant Human Caspase-10/FLICE...
H00000843-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human Caspase-10/ ...
Recombinant Human Caspase-10/FLICE...
H00000843-Q02
Species: Hu
Applications: WB, ELISA, PA
RNAi
Caspase-10/FLICE2 RNAi
Caspase-10/FLICE2 RNAi
H00000843-R01
Species: Hu
Applications: RNAi, RNAi SP
Caspase-10/FLICE2 RNAi
Caspase-10/FLICE2 RNAi
H00000843-R03
Species: Hu
Applications: RNAi, RNAi SP
Caspase-10/FLICE2 RNAi
Caspase-10/FLICE2 RNAi
H00000843-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Apoptosis, or programmed cell death, is a common property of all multicellular organisms. The current dogma of apoptosis suggests that the components of the core cell-death machinery are integral to cells and widely conserved across species. Caspases, a family of cysteinyl aspartate-specific proteases, are integral components of the cell death machinery (reviewed in Siegal, 2006; and Lavrik et al, 2005). They play a central role in the initiation and execution of apoptotic cell death and in inflammation. Caspases are typically divided into 3 major groups, depending on the structure of their prodomain and their function. Group 1: inflammatory caspases (caspases 1, 4, 5, 11, 12, 14). Group II: initiator of apoptosis caspases (caspases 2, 8, 9). Group II: effector caspases (caspases 3, 6, 7). Caspases are constitutively expressed in almost all cell types as inactive proenzymes (zymogens: enzyme precursors which require a biochemical change to become active enzymes) that are processed and activated in response to a variety of pro-apoptotic or inflammatory stimuli. The procaspases (32-56 kDa) contain four domains: an N-terminal prodomain (2-25 kDa), a large subunit (p20: 17-21 kDa), a small subunit (p10: 10-13 kDa) and a short linker region between the large and small subunits. Caspase activation involves proteolytic processing of the proenzyme at specific aspartate residues between the domains. This results in removal of the prodomain as well as the linker region and formation of a heterodimer containing one large and one small subunit (p20-p10). The active caspase is a tetramer composed of two heterodimers (p202-p102). Active caspases mediate cell death and inflammation through cleavage of particular cellular substrates that are involved in these processes. Caspase-10 is a 455 amino acid protein. However, caspase-10 produces, by alternative splicing, at least 12 different transcripts, all with introns, putatively encoding at least 11 different protein isoforms. For example, human caspase-10a is a 479 amino acid (aa) protein, and human caspase-10d is a 522 aa protein. The transcripts appear to differ by truncation of the end, presence or absence of 6 cassette exons, or common exons with different boundaries, because an internal intron is not always spliced out. Users are encoraged to go to the NCBI ACE View Data Base for more information. http://www.ncbi.nih.gov/IEB/Research/Acembly/ Caspase-10 gene mutations or polymorphisms have been associated with a number of diseases including type II autoimmune lymphoproliferative syndrome, non-Hiodgkin's lymphoma, and gastric cancer. It is thought that some mutations of the caspase-10 gene may lead to the loss of its apoptotic function, thereby contributing to the pathogenesis of some diseases. Caspase-10 may be observed on Western blots at varying apparent molecular weights depending on isoform, truncation, or cleavage forms present. Recognizes caspase-10 forms that contain the peptide immunogen sequence (QPAFTLRKKLVFPVPLDALSI).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 843
Alternate Names
  • EC 3.4.22.63
  • FAS-associated death domain protein interleukin-1B-converting enzyme 2
  • interleukin-1B-converting enzyme 2
  • FLICE2
  • FADD-like ICE2
  • CASP-10
  • caspase-10
  • Apoptotic protease Mch-4
  • caspase 10, apoptosis-related cysteine protease
  • MCH4ALPS2
  • ICE-like apoptotic protease 4
  • caspase 10, apoptosis-related cysteine peptidase

Research Areas for Caspase-10/FLICE2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Caspases

PTMs for Caspase-10/FLICE2

Learn more about PTMs related to Caspase-10/FLICE2.

Cleavage
Phosphorylation
Methylation
Demethylation
Biotinylation
Acetylation
Dephosphorylation

Bioinformatics Tool for Caspase-10/FLICE2

Discover related pathways, diseases and genes to Caspase-10/FLICE2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Caspase-10/FLICE2 Blog Posts

Check out the latest blog posts on Caspase-10/FLICE2.
Caspase 10 - an initiator caspase in the extrinsic death receptor pathway
Apoptosis, also called programmed cell death, is an essential process in development and disease. The signaling networks that carry out apoptosis is consists of a series of endoproteases called caspases which are synthesized as inactive zymogens....    Read more.
Read more Caspase-10/FLICE2 related blogs.