Hu, Mu, Rt(-)Applications:
WB, Flow, Flow-IC, ICC/IFHost:
WB, Flow, ICC/IF, CyTOF-readyHost:
Hu, Mu, RtApplications:
WB, ICC/IF, IHC, IHC-P, KDHost:
Applications: PAGE, Bioactivity
Poly (ADP-ribose) polymerase (PARP) is protein family primarily invloved in DNA repair and programmed cell death. PARP proteins are activated in response to DNA single strand breaks (SSBs). Upon SSB detection, PARP binds the DNA and synthesizes a PAR chain at the damaged site, which then signals the initiation of DNA repair by other enzymes such as XRCC1, DNA ligase III and DNA polymerase beta. After repair, the PAR chains are degraded via PAR glycohydrolase.
PARP is inactivated by caspase cleavage, leading to a programmed cell death pathway.
|Product By Gene ID
- PARP apoptosis
- NAD(+) ADP-ribosyltransferase 1
- EC 2.4.2
- ADPRT 1
- poly(ADP-ribose) synthetase
- poly(ADP-ribose) polymerase
- Poly[ADP-ribose] synthase 1
- poly (ADP-ribose) polymerase family, member 1
- poly [ADP-ribose] polymerase 1
- ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
- ADPRTADP-ribosyltransferase NAD(+)
- EC 188.8.131.52
- poly (ADP-ribose) polymerase 1
Bioinformatics Tool for PARP
Discover related pathways, diseases and genes to PARP. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.
Related PARP Blog Posts
Check out the latest blog posts on PARP.
Read more PARP related blogs.
|What are the major differences between Apoptosis, Necroptosis & Autophagy?
Apoptosis is a form of programmed cell death which is mediated by cysteine proteases called caspases. It is an essential phenomenon in the maintenance of homeostasis and growth of tissues, and it also plays a critical role in immune response. The ... Read more.
|The role of PARP-1 in the repair of single stranded break (SSB)
PARPs (poly ADP ribose polymerases) are DNA repair enzymes that promote single stranded break (SSB) repair by binding to DNA at the sites of SSBs and recruiting repair machinery. In humans, the PARP superfamily consists of 17 members, of which five... Read more.
|Caspase 3 - a Reliable Marker for Index of Apoptosis Induction
Caspase-3 is one of the most important players in apoptosis signaling. It is synthesized as an inactive 32 kDa pro-enzyme and upon direct activation by Caspase-8, -9 or -10, it gets processed into its active forms, the p17-20 and p10-12 subunits. T... Read more.
|Caspase 7 - A key effector of the apoptotic pathway
Caspase-7 is an effector caspase with important roles in mediating cell death signaling. As an effector caspase, caspase-7 is cleaved and activated by initiator caspases such as caspase-1 (1). Like other caspase family proteins, caspase-7 contains a... Read more.
|Caspase 7: The Cell's Suicide Switch
Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all... Read more.
|PARP Antibody Assays aid both Apoptosis and Cancer Research
The PARP (Poly(ADP-ribose) polymerase) protein is a zinc-dependant nuclear enzyme whose main role is to detect and repair DNA single-strand breaks (SSB). However, PARP antibody research has revealed there are at least 17 PARP proteins, which also play... Read more.