Antibody suppliers

MMP2 is an extracellular matrix degradative peptidase enzyme that belongs to the large family of matrix metalloproteinases (MMPs) which each have different substrate specificities. Aberrant or derailed expression of various MMPs through loss of negative checks is strongly associated with tumor invasion, metastasis, and angiogenesis, as compared to tightly controlled physiological processes such as tissue remodeling, rebuilding, and embryonic development.

TREM1 is pro-inflammatory gene that stimulates neutrophil and monocyte-mediated inflammatory responses. This protein is highly expressed in adult liver, lung and spleen. It is also present in the lymph node, spinal cord and heart tissues. TREM-1 plays a critical role in acute inflammatory responses to bacteria. In organs such as the liver, damage occurring due to irritants such as alcohol causes TREM-1 to amplify the inflammatory response by mediating a signalling pathway.

AH receptor-interacting protein (AIP) is a 37 kD immunophilin-like factor found in a variety of tissues with expression levels ranging from high (spleen, thymus, pituitary heart, placenta and skeletal muscle) to low (liver, kidney and lung). It mediates aryl hydrocarbon receptor (AhR) signaling either through ligand receptivity and/or modulating nuclear targeting and has been shown to bind to both the AhR itself as well as the AhR nuclear translocator (ARNT).

ABCA1 is a key gatekeeper influencing intracellular cholesterol transport, and is an important member of a multifamily of cAMP-dependent anion transporter cell membrane proteins that regulate reverse cholesterol efflux from cells in peripheral tissues to apolipoprotein A1. ABCA1 has a wide expression profile with highest expression levels found in macrophages.

Cre (Cyclization recombination enzyme) is a member of the large family of recombinases. Cre recognizes Lox site loxP, a 34 bp sequence motif from the PI bateriophage. If a DNA segment is flanked by two loxP sites in the same orientation, Cre neatly excises the segment (for later degradation) leaving a single remaining loxP site in the DNA molecule. The Cre/Lox system was first developed in the late 1980's to artificially manipulate gene expression and extensive reviews of the system exist (1).

APE1 is involved in repairing oxidative DNA damages in vitro, regulates the redox of transcriptional factors, repairs AP sites in DNA, and is important for embryonic development in mice. Learn more about APE1 in our infographic below.

Novus Biologicals offers APE1 reagents for your research needs including:

53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophase/cytokinesis phase in mitotic mammalian cells (1).

HSP70 family member GRP78 (78 kD glucose-regulated protein) is an abundant protein cofactor commonly known as a molecular chaperone. Found in most eukaryotes, Hsp genes are members of a heat-inducible multigene family.

NOX4 is an NADPH oxidase that generates superoxide within the cell. It is primarily found in vascular cells, fibroblasts, and osteoclasts, with abundant expression in the kidney. Unlike its family members NOX1 and NOX2, NOX4 is constitutively active, producing primarily H2O2 rather than O2. This different species generated triggers NOX4-specific actions in downstream cell signaling.