CD34 Serves as an Important Marker in Disease Research

Wed, 12/04/2013 - 12:25

CD34 is a membrane protein that aids cells in cell-cell adhesion. Although little is known about its function, CD34 is an important marker for hematopoietic stem cells (HSCs), muscle satellite cells, and endothelial cells. HSCs can be found in bone marrow and blood of adults; however, because they are relatively rare, historically, HSCs have been difficult to study.  The emergence of flow cytometry and FACS has facilitated the use of antibodies against CD34 to more readily identify, count and even purify these cells.  Researchers most often extract HSCs from umbilical cord blood which is a rich source of these rare cells (1).

Immunocytochemistry/Immunofluorescence: CD34 Antibody Immunocytochemistry/Immunofluorescence: CD34 Antibody

Current research has focused CD34 as a prognostic indicator in tumors. In a recent study, investigators reported that CD34 expression is significantly lower in malignant tumors compared to their benign counterparts (2). CD34 is also used to distinguish between different subtypes of a particular cancer such as acute leukemia (3). The role of CD34, and HSC like cells in cancer is just beginning to emerge, but given the intensity of ongoing studies, this field will be an exciting area of research to follow in the near term.

  1. PMID: 23822622
  2. PMID: 23772632
  3. PMID: 23730015

Novus Biologicals offers CD34 reagents for your research needs including:

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