Antibody suppliers

Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in squamous cell carcinoma and overexpression of IKK-α in the skin of these mice abrogates tumor formation (1).

DNA-methyltransferase 3B (DNMT3B), also known as DNA methyltransferase HsaIIIB, is a member of the class I-like SAM-binding methyltransferase superfamily and C5-methyltransferase family. DNMT3B plays an essential role in the establishment of DNA methylation patterns during development and is vital for genome-wide de novo methylation.

OXPAT is the mammalian form of the PAT (perilipin, adipophilin, and TIP47) gene family that consists of proteins associated with lipid droplets (LDs) in fat-storing adipocyte cells.

Apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays an important role in the DNA base excision repair pathway.

Nuclear Mitotic Apparatus protein (NuMA) is a cell cycle-related protein that acts as an organizer of the mitotic spindle during mitosis. It may be involved in coordinating the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell division. NuMA is also a prominent component of interphase cell nuclear matrix; however its role during interphase is largely unknown.

Centromere protein F (CENPF) also known as Mitosin, AH antigen, and kinetochore protein CENPF, is a protein that associates with the centromere-kinetochore complex. CENPF forms both a homodimer and a heterodimer. CENPF can be found in different cellular locations depending on the stage of mitosis.

The availability of commercial antibodies for a myriad of scientific applications has had a profound positive impact on life science research. It's not surprising that the global antibody market, including therapeutics, diagnostics, and research, is now estimated at $70-75 billion.

And yet, almost half of 400 antibody users surveyed by 1DegreeBio in 2012 reported that that in 50% of cases, their antibodies did not work as expected. That’s a lot of failed experiments—and a lot of money wasted.

NeuN is a RNA-binding protein that modulates alternative splicing and is localized both to the nucleus and cytoplasm. It is a member of the RNA-binding FOX (RBFOX) family of splicing regulators which includes RBFOX1 (Fox-1/A2BP1) and RBFOX2 (Fox-2/RBM9). Each FOX family member is differentially expressed – RBFOX1 in neurons, heart, and muscle while RBFOX3 is exclusively limited to neurons.

Synaptonemal Complex Protein 3 (SCP3), which is a protein present in the synaptonemal complex which is responsible for pairing, synapsis, and recombination of homologous chromosomes during meiosis. Meiosis, in basic terms, is where germ cells divide to produce gametes. This is accomplished through DNA replication and two rounds of cell division.