Antibody catalog

LC3B is subunit component of the LC3 autophagy biomarker associated with microtubule-associated proteins MAP1A and MAP1B and one of the best characterized markers to date. In resting state, it is cytosolic, but upon activation, is lapidated and becomes embedded in the autophagosomal membrane.

CD34 is a cell surface glycoprotein that aids cells in cell-cell adhesion. It is expressed on endothelial cells where it is known to bind L-selectin and may aid in migration of T-cells.

VEGF Receptor 1 plays a critical role in vasculogenesis, angiogenesis, cell migration, cell survival, chemotaxis and cancer cell invasion. Learn more about VEGF Receptor 1 in the infographic below.

Novus Biologicals offers various VEGF Receptor 1 reagents for your research needs including:

53BP1 (p53 binding protein 1) was originally thought to be a p53 transcriptional enhancing partner, but now has been shown to be an ataxia telangiectasia mutated (ATM) substrate. It is a late DNA damage response (DDR) marker, appearing in the telophase/cytokinesis phase in mitotic mammalian cells (1).

70-kDa Heat Shock Protein (Hsp70) is an abundant protein cofactor commonly known as a molecular chaperone. Found in most eukaryotes, Hsp genes are members of a heat-inducible multigene family. These proteins are found in most cellular compartments of eukaryotes - everything from nuclei, mitochondria, chloroplasts, to endoplasmic reticulum and cytosol.

PIEZO1, and its close homologue PIEZO2, are mechanosensitive ion channel proteins. Mechanosensitive ion channels couple protein conformation to the mechanics of the surrounding membrane, and switch between a closed state and an open state in response to changes in membrane tension, thickness, or curvature. Cells use this information to ensure viability under conditions of osmotic stress or membrane deformation (1).

Survivin is an anti-apoptotic protein from a large family with related members such as X-linked IAP, cIAP1 and cIAP2, IAP-like protein-2, melanoma IAP, Livin, and NAIP. Survivin regulates fundamental physiological events including the cell cycle, fetal development, and cell migration.

Hypoxia inducible factors (HIFs) are transcription factors that regulate the cellular response to decreases in oxygen levels. Under conditions of hypoxia HIFs activate the transcription of a diverse range of genes, resulting in increased oxygen delivery to the cell or metabolic adaptation.

GPR49/LGR5 (G protein-coupled receptor 49/leucine-rich repeat-containing G protein-coupled receptor 5) is also known by the names FEX, GPR67, GRP49, HG38, and MGC117008). It is an orphan receptor and structurally related to members of the mammalian large transmembrane glycoprotein hormone receptor family (FSH-R, TSH-R, and LH-R).

TRF2 (telomeric repeat-binding factor 2) is a homodimeric protein that binds the double-stranded 5'-TTAGGG-3' repeat in telomeres.