PIEZO1 antibody

PIEZO1, and its close homologue PIEZO2, are mechanosensitive ion channel proteins. Mechanosensitive ion channels couple protein conformation to the mechanics of the surrounding membrane, and switch between a closed state and an open state in response to changes in membrane tension, thickness, or curvature. Cells use this information to ensure viability under conditions of osmotic stress or membrane deformation (1).