Antibodies

TRPV1: Show Me Where it Hurts

Carbonic anhydrase IX (CAIX) is a member of the carbonic anhydrase family - enzymes that enable the rapid conversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. Carbonic anhydrases have a widespread role in regulating pH in normal tissues and are abundantly found in all mammalian tissues. CAIX itself is one of the most hypoxically-inducible genes due to its stability and membrane location.

The process of smelling, also known as olfaction, involves thousands of olfactory receptors that transmit signals to the brain. Learn more about the olfactory process in the infographic below.

Novus Biologicals offers olfactory related research reagents including:

Actins are extremely highly conserved structural proteins found in all eukaryotic cell cytoskeletons that govern cell structure, movement, and shape integrity. Six distinct actin isoforms, each encoded by a different gene and developmentally-regulated as well as tissue-specific-regulated, have been identified in mammalian cells. The alpha and beta isotypes are cytoplasmic and expressed in a wide variety of cells.

ATG5 is a member of the ATG family that regulates autophagy, the evolutionary conserved homeostatic response to a diverse variety of self- and foreign-originating cellular stresses. ATG5 is ubiquitously expressed in cells and found co-localized with cytoplasmic non-muscle actin under normal resting conditions, but upon the triggering of apoptosis, ATG5 expression dramatically ramps up, and ATG5 directly conjugates with other related ATG family proteins to form autophagosomes.

GAPDH is a 146 kDa tetramer metabolic enzyme within the glycolytic pathway that reversibly oxidatively phosphorylates glyceraldehyde 3-phosphate. It may have other additional functions in transcriptional activation. It is highly expressed due to its housekeeping functional role, and the prevalent expression of GAPDH has facilitated its use as an internal loading control – traditionally for mRNA expression comparisons – but also in protein studies.

The sense of taste involves the reaction of chemicals with nerve cells which send messages to the brain to create the perception of flavor. Learn more about taste and in the infographic below.

Novus Biologicals offers research reagents mentioned in this infographic including:

Fanconi anemia (FANC) is a heterogenous, autosomal-recessive cancer susceptibility genetic disorder that is characterized by a wide array of symptoms, including congenital defects, progressive bone marrow failure due to DNA-damage hypersensitivity, chromosomal instability, and poor DNA repair. The protein FANCD2 is involved in mediating cellular resistance to DNA cross-linking and DNA synthesis arrest that is triggered by ionizing radiation (IR).

Eukaryotic chromosomes are formed through the highly organized and structural wrapping of DNA genetic material around histone proteins into the classic "bead on a string" globular structure of nucleosomes. The histone family consists of five family members - histone H1, H2A, H2B, H3, and H4.

Beclin 1 is the first mammalian gene identified as a mediator of autophagy, and plays important roles in development, tumorigenesis, and neurodegeneration.