Antibodies

Alzheimer's disease is a progressive neurodegenerative disease that impacts cognitive function. Research is currently being done to understand different genetic, environmental and biological factors which contribute to the disease to find a cure. Learn more in our infographic about Alzheimer's disease below.

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Parkinson's disease affects the nervous system which controls movement. Damage to the levels of dopamine in the brain impairs the ability to relay messages to parts of the body which control movement. While the exact cause of the disease is unknown, researchers are examining genetic causes linked to the LRRK2 gene and environmental factors.

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The Myc gene family of proto-oncogenes consists of nuclear transcription factors that include l-Myc, n-Myc and c-Myc. They are key players in fundamental processes such as cellular proliferation, differentiation, apoptosis, metabolism, and adhesion.

The neurokinin 1 receptor (NK1), commonly referred to as tachykinin receptor 1, is a 401 amino acid, 46 kDA protein encoded by the TACR1 gene localized on chromosome 2 (2p13.1-p12).

The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for the recognition of objects, ability to discern textures and provide feedback on sensory-motor systems. 

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a toxin, named after the plant genus Plumbago from which it was first isolated in 1968 (1). Since its discovery there have been a wide variety of publications describing its effects on fertility, hyperlipedaemia (high cholesterol) and its use as an anti-bacterial. More recently, there have been multiple efforts to synthesise derivatives and analogues of plumbagin in order to increase its potential as an anti-cancer agent.

Histones are highly conserved proteins that function in the organization of nuclear DNA to create chromatin in eukaryotic cells. Post-translational alterations of histones are critical to monitoring and regulating DNA structure, expression, and gene transcription.

Co-factor of BRCA1, also known as COBRA1, was first identified as a protein that binds to the tumour suppressor protein encoded by the breast cancer susceptibility gene BRCA1 (1). It was subsequently found to be identical to subunit B of the Negative Elongation Factor (NELF) complex (2). NELF is composed of four subunits (A, B, C or D, and E) and plays a pivotal role in the transcriptional pausing of RNA polymerase II.

The auditory process involves several structures of the ear to convert sound waves into information that is processed by our brain. Learn more about the auditory process in our infographic below. Novus Biologicals offers reagents mentioned in the infographic including:

The SM047 antibody is an IgM monoclonal antibody that was developed by McCluggage's group at the UK Royal Group of Hospitals and recognizes a multivalent antigen from ovarian carcinoma (OvC) cells (1). Early studies indicate that the epitope is specifically expressed in the adenocarcinoma glycocalyx, and is most strongly expressed in serous OvC subtypes.