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histochemical marker

Marking Hypoxia and Cancer with CAIX

Carbonic anhydrase IX (CAIX) is a member of the carbonic anhydrase family - enzymes that enable the rapid conversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. Carbonic anhydrases have a widespread role in regulating pH in normal tissues and are abundantly found in all mammalian tissues. CAIX itself is one of the most hypoxically-inducible genes due to its stability and membrane location.