SM047: A Powerful Ovarian Carcinoma Marker

Mon, 10/28/2013 - 12:06

The SM047 antibody is an IgM monoclonal antibody that was developed by McCluggage's group at the UK Royal Group of Hospitals and recognizes a multivalent antigen from ovarian carcinoma (OvC) cells (1). Early studies indicate that the epitope is specifically expressed in the adenocarcinoma glycocalyx, and is most strongly expressed in serous OvC subtypes. Further work has established the SM047 antibody as an ovarian-specific immunohistochemical (IHC) marker within a larger panel capable of distinguishing between adenocarcinomas of non-mucinous versus colonic origin.  The creators of the SM047 antibody have also successfully investigated similar diagnostic applications in patient peritoneal fluid cytological preparations (2).

Western Blot: SM047 Antibody Western Blot: SM047 Antibody
  1. PMID: 11422498
  2. PMID: 12588308

Novus Biologicals offers SM047 Antibodies for your research needs.

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