ABCG8 Products

Antibodies
Lysates
ABCG8 Overexpression Lysate
ABCG8 Overexpression Lysate
NBP2-06444
Species: Hu
Applications: WB
Proteins
ABCG8 Antibody Blocking Pepti ...
ABCG8 Antibody Blocking Peptide
NB400-110PEP
Species: Hu
Applications: AC
ABCG8 Recombinant Protein Ant ...
ABCG8 Recombinant Protein Antigen
NBP1-83388PEP
Species: Hu
Applications: AC

Description

ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.

Bioinformatics

Product By Gene ID 64241
Alternate Names
  • ATP-binding cassette sub-family G member 8
  • ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2)
  • ATP-binding cassette, sub-family G (WHITE), member 8
  • GBD4ATP-binding cassette, subfamily G, member 8
  • MGC142217
  • sterolin 2
  • sterolin-2
  • STSL

Research Areas for ABCG8

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction

Related ABCG8 Blog Posts

Check out the latest blog posts on ABCG8.
Understanding Sitosterolemia: How ABCG5-ABCG8 Dimer Affects Blood Sterol Levels
The ATP binding cassette (ABC) transporter family is the largest and most diverse family of membrane transport proteins and, as the name suggests, uses the energy generated by ATP hydrolysis to transport substrates across membranes. Eukaryotic ABC tra...    Read more.
ABCG2: A Tumor Protector
ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1). The ABC transporters...    Read more.
Exploring how ABCG8 Affects Heart Disease
The high prevalence of atherosclerosis in developed nations is not breaking news; it has been well established that heart disease is the leading cause of death in the United States, and it presents a major socioeconomic burden. Investigators across th...    Read more.
Read more ABCG8 related blogs.