ABCG8 Products

Description

ATP-binding cassette sub-family G member 8 (ABCG8) is a member of the superfamily of ATP-binding cassette transporters and a member of the White subfamily.

Transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. Specifically, ABCG8 is responsible for the selective transport of dietary cholesterol in/out of the enterocytes and in the selective liver sterol excretion into bile. ABCG8 also cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols.

ABCG8 is highly expressed in the liver and intestine. Mutated forms of ABCG8 lead to sterol accumulation and can cause atherosclerosis or sitosterolemia, a rare autosomal recessive disorder characterized by hyperabsorption of sterols and the inability to excrete sterols into bile.

ABCG8 antibodies are useful tools for cholesterol absorbtion/sectretion studies and are fundamental to the understanding of certian liver functions.

Bioinformatics

Entrez	64241 Human 67470 Mouse
Uniprot	NP_071882 Human Q9DBM0 Mouse Q9H221 Human
Product By Gene ID	64241
Alternate Names	ATP-binding cassette sub-family G member 8 ATP-binding cassette, sub-family G (WHITE), member 8 (sterolin 2) ATP-binding cassette, sub-family G (WHITE), member 8 GBD4ATP-binding cassette, subfamily G, member 8 MGC142217 sterolin 2 Sterolin-2 sterolin-2 STSL

Research Areas for ABCG8

Find related products by research area and learn more about each of the different research areas below.

ABC Transporters
Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction

Related ABCG8 Blog Posts

Check out the latest blog posts on ABCG8.

Exploring how ABCG8 Affects Heart Disease The high prevalence of atherosclerosis in developed nations is not breaking news; it has been well established that heart disease is the leading cause of death in the United States, and it presents a major socioeconomic burden. Investigators across th...    Read more.

ABCG2: A Tumor Protector ABCG2 is a member of the ATP-binding cassette (ABC) transporter superfamily. Among ABC transporters ABCG2 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure (1). The ABC transporters...    Read more.

Understanding Sitosterolemia: How ABCG5-ABCG8 Dimer Affects Blood Sterol Levels The ATP binding cassette (ABC) transporter family is the largest and most diverse family of membrane transport proteins and, as the name suggests, uses the energy generated by ATP hydrolysis to transport substrates across membranes. Eukaryotic ABC tra...    Read more.

Read more ABCG8 related blogs.