VIPR1/VPAC1 Antibody

Product Discontinued

VIPR1/VPAC1 Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human VIP Receptor 1.
• Localization: Plasma membrane
• Specificity: Human VIP Receptor 1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GHRHR (56%).
• Predicted Species: Monkey (94%), Primate (94%), Rabbit (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VIPR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (94%), Hamster (81%), Porcine (81%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for VIPR1/VPAC1 Antibody

• FLJ41949
• HVR1
• II
• PACAP type II receptor
• PACAP-R2
• RDC1
• type II
• V1RG
• vasoactive intestinal peptide receptor 1
• vasoactive intestinal polypeptide receptor 1
• VIP R1
• VIP receptor, type I
• VIPR
• VIPR1
• VPAC1
• VPAC1R

Background

Vasoactive Intestinal Polypeptide Receptor 1 (VIPR1) is a member of the Vasoactive Intestinal Polypeptide subfamily. Vasoactive intestinal peptide (VIP) plays multiple roles in the nervous, endocrine, and immune systems as a neurotransmitter, a hormone, and a cytokine. VIPR1, a receptor for VIP, has been shown to expressed widely in normal tissues and is the predominant receptor subtype for VIP in cancers. VIP and its receptors, VIPR1 and VIPR2, are highly expressed in the immune system and modulate diverse T cell functions. Recently VIP-R1 has been shown to be a novel and potent facilitator of HIV-1 infection. Two isoforms are produced by alternative splicing. VIPR1 expression has been documented widely in normal and cancerous tissues, including adipose, adrenal, bladder, blood, brain, breast, colon, ganglion, GI tract, heart, kidney, liver, lung, lymph node, ovary, pancreas, placenta, prostate, skin, small intestine, spinal cord, spleen, stomach, testis, thymus, thyroid, and vessel. ESTs have been isolated from a diverse set of normal and cancerous tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for VIPR1/VPAC1 Antibody (NLS1296)(1)

Publication using NLS1296

• Berger EA, Vistisen KS, Barrett RP, Hazlett LD. Effects of VIP on corneal reconstitution and homeostasis following Pseudomonas aeruginosa induced keratitis Invest Ophthalmol Vis Sci 2012-10-04 [PMID: 23036997]

Bioinformatics

• Gene Symbol: VIPR1
• Entrez:
  • 7433(Human)