V2 Vasopressin R/AVPR2 Antibody

Images

 
Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS273] - Anti-AVPR2 / V2R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced ...read more
Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS273] - Analysis anti-AVPR2 antibody with kidney, renal tubules at 3 ug/ ml.
Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS273] - Analysis of anti-AVPR2 / V2R antibody with human colon, carcinoma.

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

V2 Vasopressin R/AVPR2 Antibody Summary

Immunogen
Synthetic 15 amino acid peptide from C-terminus of human AVPR2.
Specificity
Human AVPR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
AVPR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 1:10 - 1:500
Positive Control
V2 Vasopressin R/AVPR2 Lysate (NBL1-07867)

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Baboon (100%), Marmoset (87%), Panda (87%), Canine (80%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for V2 Vasopressin R/AVPR2 Antibody

  • ADHR
  • ADHRMGC138386
  • Antidiuretic hormone receptor
  • arginine vasopressin receptor 2
  • AVPR V2
  • AVPR2
  • DI1
  • DIR3
  • DIRNDI
  • NDI
  • Renal-type arginine vasopressin receptor
  • V2 Vasopressin R
  • V2 VasopressinR
  • V2R
  • V2RMGC126533
  • vasopressin V2 receptor

Background

The human AVPR2 locus encodes vasopressin receptor type 2, a member of the vasopressin/oxytocin family subfamily. V2 receptor has been shown to concentrate the urine and maintain water homeostasis by responding to the pituitary hormone arginine vasopressin (AVP). Loss of gene function results in the disease Nephrogenic Diabetes Insipidus (NDI). When extrarenal V2 receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known; its absence does not appear to be detrimental in NDI patients. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts. The V2 Receptor is also expressed outside the kidney although its tissue localization is uncertain. AVPR2 expression has also been described in brain, breast, fetal lung tissue and lung cancer associated with alternative splicing. ESTs have been isolated from normal lung and pancreatic cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol AVPR2
Entrez