TREML4/TLT-4 Antibody [Biotin]

• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

TREML4/TLT-4 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse TREML4/TLT‑4
  Ser25-Val195
  Accession # NP_001029094
• Specificity: Detects mouse TREML4/TLT‑4 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human TREM1, recombinant mouse (rm) TREM2b, and rmTREM3 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: Treml4
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

TREML4 (Triggering receptor expressed on myeloid cells-like 4; also TLT4) is a 29 kDa (predicted) member of the Ig superfamily. It is likely expressed by leukocytes and based on its structure, may act as an activating receptor. Mature mouse TREML4 is a type I transmembrane (TM) protein 235 amino acids (aa) in length. It contains a 171 aa extracellular region (aa 29‑199) with a V-type Ig-like domain (aa 29‑122); the TM segment contains one Lys residue. There is one splice variant that shows a deletion of aa 21‑24, a segment that lies in the putative signal sequence. Rodent and human TREML4 are highly divergent and thus over aa 25‑195, mouse TREML4 shares 78% aa identity with rat TREML4, but only 52% aa identity with human TREML4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: Treml4