TMEM59 Antibody - BSA Free

Western Blot: TMEM59 Antibody [NBP1-76497] - Human kidney tissue lysate with TMEM59 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

Immunocytochemistry/ Immunofluorescence: TMEM59 Antibody - BSA Free [NBP1-76497] - Immunofluorescence of TMEM59 in human kidney tissue with TMEM59 antibody at 20 u/mL.

Immunohistochemistry: TMEM59 Antibody - BSA Free [NBP1-76497] - Immunohistochemistry of TMEM59 in human kidney tissue with TMEM59 antibody at 2.5 u/mL.

• Reactivity: Hu, Mu, Po, Bv
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TMEM59 Antibody - BSA Free Summary

• Immunogen: Antibody was raised against a 16 amino acid synthetic peptide near amino terminus of human TMEM59. The immunogen is located within amino acids 80 - 130 of TMEM59. Amino Acid Squence: ECESACTEAYSQSDEQ
• Predicted Species: Mouse (94%), Porcine (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TMEM59
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 1 ug/ml
• Control Peptide:

  TMEM59 Peptide (NBP1-76497PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TMEM59 Antibody - BSA Free

• C1orf8
• chromosome 1 open reading frame 8
• DCF1
• FLJ42977
• HSPC001
• Liver membrane-bound protein
• PRO195
• TMEM59
• transmembrane protein 59
• UNQ169

Background

Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59, a Golgi-localized protein, modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. It inhibits APP transport and shedding.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TMEM59
• Uniprot:
  • NP_004863()