SRCAP Antibody

Product Discontinued

SRCAP Antibody Summary

• Immunogen: Peptide with sequence C-DEAQNIKNFKSQR corresponding to internal region according to NP_006653.2.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SRCAP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunofluorescence 10 ug/ml
  • Peptide ELISA Detection limit 1:8000

Reactivity Notes

Expected from sequence similarity: Mouse, Rat, Dog.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SRCAP Antibody

• domino homolog 1
• Domino homolog 2
• DOMO1
• EAF1
• EC 3.6.1
• EC 3.6.4.-
• FLJ44499
• KIAA0309helicase SRCAP
• Snf2-related CBP activator
• Snf2-related CREBBP activator protein
• Swi2/Snf2-related ATPase homolog, domino homolog 1
• SWR1Snf2-related CBP activator protein

Background

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SRCAP Antibody (NBP1-45244)(2)

Publications using NBP1-45244

• Thomsen I, Kunowska N, de Souza R Et al. RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells Journal of immunology (Baltimore, Md. : 1950) 2021-11-22 [PMID: 34810221] (Chip Cytometry, Mouse)
• Wong MM, Cox LK, Chrivia JC. The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. J Biol Chem 2007-09-01 [PMID: 17617668]

Bioinformatics

• Gene Symbol: SRCAP
• Entrez:
  • 10847(Human)
  • 100043597(Mouse)
  • 361652(Rat)
• Uniprot:
  • NP_006653.2(Human)