SIRPB2 Antibody (1008709) [Alexa Fluor® 750]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
1008709
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 750

SIRPB2 Antibody (1008709) [Alexa Fluor® 750] Summary

Immunogen
HEK293 human embryonic kidney cell line, HEK293 derived human SIRP beta 2
Gln33-Gly287
Accession # Q5JXA9
Specificity
Detects human SIRP beta 2 in direct ELISAs.
Source
N/A
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SIRPB2 Antibody (1008709) [Alexa Fluor® 750]

  • dJ776F14.2
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1-Like 3
  • Protein Tyrosine Phosphatase Non-Receptor Type Substrate Protein
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1-Like
  • Protein Tyrosine Phosphatase, Non-Receptor Type Substrate 1-Like 3
  • PTPN1L
  • PTPNS1L3
  • Signal-Regulatory Protein Beta 2
  • Signal-Regulatory Protein Beta-2
  • SIRP beta 2
  • SIRP-beta-2
  • SIRPG

Background

Signal-regulatory protein beta-2(SIRP-beta-2), is a ~37 kDa monomeric single pass type I membrane glycoprotein. It belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily (1). The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions (1). SIRP-beta-2 contains an N-terminal signal peptide (aa1-32), two extracellular Ig-like domains: a V-type 1 (aa 33-143) and a V-type 2 (aa 157-258) containing three potential N-linked glycosylation sites, a helical transmembrane domain (aa 288-308), and a cytoplasmic domain (aa 309-342) (1). A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) (2). Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages (3). Based on expression patterns, SIRPs are thought to have roles in immune regulation (4). SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation (5, 6). There are currently no known mouse or rat homologs for this protein.
  1. van Beek, E.M. et al. (2005) J. Immunol. 175:7781.
  2. Liu, Y. et al. (2005) Journal of Biological Chemistry. 280:36132.
  3. Matozaki, T. et al. (2009) Trends in Cell Biology. 19:72.
  4. Barclay A.N. et al. (2006) Nat Rev Immunol. 6:457.
  5. Barclay A.N. et al. (2014) Annu Rev Immunol. 32:25.
  6. Veillette A. (2018) Trends Immunol. 39:173.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 FAB9998U
Alexa Fluor 405 FAB9998V
Alexa Fluor 488 FAB9998G
Alexa Fluor 594 FAB9998T
Alexa Fluor 647 FAB9998R
Alexa Fluor 700 FAB9998N
Alexa Fluor 750 FAB9998S

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